Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.50 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.67 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.67 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.55 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.55 |
| ▸ | BLM | P54132 | 3/20 | 0.55 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | GABRP | O00591 | 3/20 | 0.38 |
| ▸ | GABRD | O14764 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4204452 | 1.00 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Maleic Acid SCHEMBL558296 | 1.00 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Glycine SCHEMBL558371 | 0.89 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Glycine SCHEMBL558369 | 0.89 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Crotonic Acid SCHEMBL28145066 | 0.83 | GLRA1 (0.53) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Maleic Acid SCHEMBL18065037 | 0.83 | TSHR (0.64) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Maleic Acid SCHEMBL786851 | 0.83 | TSHR (0.64) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Fumaric Acid SCHEMBL2840791 | 0.83 | TSHR (0.64) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Fumaric Acid SCHEMBL18065038 | 0.83 | TSHR (0.64) | GLRA1SLC6A9OR51E2TSHRTP53 | |
| Fumaric Acid SCHEMBL786567 | 0.83 | TSHR (0.64) | GLRA1SLC6A9OR51E2TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3263117-A1 | ORAL THERAPEUTIC COMPOUND DELIVERY SYSTEM | IMAGINOT PTY LTD. (AU) | 2018-01-03 | — | — | EP | claimed |
| EP-3216445-A1 | ORAL THERAPEUTIC COMPOUND DELIVERY SYSTEM | IMAGINOT PTY LTD. (AU) | 2017-09-13 | — | — | EP | claimed |
| US-9757455-B2 | Oral therapeutic compound delivery system | JOHNSON & JOHNSON CONSUMER INC. (US) | 2017-09-12 | — | — | US | claimed |
| CN-106581755-A | Antibacterial fibroin-based bionic coating and preparation method thereof | 苏州纳贝通环境科技有限公司 | 2017-04-26 | — | — | CN | claimed |
| CN-106540316-A | A kind of antibacterial liquid medical dressing and preparation method thereof | 苏州艾博迈尔新材料有限公司 | 2017-03-29 | — | — | CN | claimed |
| EP-1750677-B1 | ORAL THERAPEUTIC COMPOUND DELIVERY SYSTEM | IMAGINOT PTY LTD (AU) | 2017-02-01 | — | — | EP | claimed |
| CN-106279575-A | A kind of temperature sensitive type composite aquogel and preparation method thereof | 林春梅 | 2017-01-04 | — | — | CN | claimed |
| CN-106237374-A | A kind of medical antibacterial aerogel dressing and preparation method thereof | 林春梅 | 2016-12-21 | — | — | CN | claimed |
| CN-104419326-A | Slurry composition for chemical mechanical polishing | COWON INNOTECH INC | 2015-03-18 | — | — | CN | claimed |
| CN-103923765-A | Detergent Composition For Process Of Manufacturing Semiconductors And Displays | COWON INNOTECH INC | 2014-07-16 | — | — | CN | claimed |
| US-20130065885-A1 | ORAL THERAPEUTIC COMPOUND DELIVERY SYSTEM | IMAGINOT PTY LTD. (AU) | 2013-03-14 | — | — | US | claimed |
| US-20090311327-A1 | Oral Therapeutic Compound Delivery System | IMAGINOT PTY LTD (AU) | 2009-12-17 | — | — | US | claimed |
| US-20080287456-A1 | Oral Therapeutic Compound Delivery System | IMAGINOT PTY LTD (AU) | 2008-11-20 | — | — | US | claimed |
| EP-1954298-A1 | ORAL THERAPEUTIC COMPOUND DELIVERY SYSTEM | Imaginot Pty Ltd. (AU) | 2008-08-13 | — | — | EP | claimed |
| WO-2007059591-A1 | ORAL THERAPEUTIC COMPOUND DELIVERY SYSTEM | IMAGINOT PTY LTD (AU) | 2007-05-31 | — | — | WO | claimed |
| EP-1750677-A1 | ORAL THERAPEUTIC COMPOUND DELIVERY SYSTEM | Imaginot Pty Ltd. (AU) | 2007-02-14 | — | — | EP | claimed |
| WO-2005115345-A1 | ORAL THERAPEUTIC COMPOUND DELIVERY SYSTEM | IMAGINOT PTY LTD (AU) | 2005-12-08 | — | — | WO | claimed |
| CN-109054648-A | Serosity combination for chemically mechanical polishing | LTCAM有限公司 | 2018-12-21 | — | — | CN | disclosed |
| US-20050276847-A1 | Oral delivery system | IMAGINOT PTY LTD. (AU) | 2005-12-15 | — | — | US | disclosed |
| WO-2005115345-A1 | ORAL THERAPEUTIC COMPOUND DELIVERY SYSTEM | IMAGINOT PTY LTD (AU) | 2005-12-08 | — | — | WO | disclosed |