Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5583500 | 0.84 | CSNK2A2 (0.34) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27723786 | 0.82 | CSNK2A2 (0.38) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL5583814 | 0.77 | LMNA (0.41) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL5595895 | 0.77 | MAPT (0.38) | NPC1ALDH1A1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4712286 | 0.76 | TACR1 (0.38) | — | |
| SCHEMBL4596816 | 0.75 | DHFR (0.40) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4596811 | 0.74 | HTR7 (0.32) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4228664 | 0.73 | PRKAB2 (0.44) | NPC1ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL4608722 | 0.69 | HTR2A (0.32) | — | |
| SCHEMBL27723765 | 0.68 | HTR1A (0.33) | NPC1ALDH1A1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |