SCHEMBL5583758

SCHEMBL5583758

Cc1ccc(Oc2cc[c]cc2C(F)(F)F)cc1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
AR P10275 11/20 0.47
HTR2A P28223 2/20 0.43
SLC6A4 P31645 2/20 0.43
KCNH2 Q12809 1/20 0.43
TEAD4 Q15561 1/20 0.35
MAPT P10636 2/20 0.34
MAPK1 P28482 1/20 0.34
ALDH1A1 P00352 1/20 0.34
POLB P06746 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
PLA2G7 Q13093 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5583620 0.85 L3MBTL1 (0.39) HTR2ASLC6A4KCNH2MAPT
SCHEMBL5583698 0.83 AR (0.37) ARMAPTKMT2A
SCHEMBL2268413 0.78 TEAD4 (0.41) ARHTR2ASLC6A4KCNH2TEAD4
SCHEMBL10001987 0.76 AR (0.51) ARHTR2ASLC6A4KCNH2TEAD4
SCHEMBL330035 0.75 AR (0.36) ARHTR2AALDH1A1
SCHEMBL5583577 0.75 HTR2A (0.42) ARHTR2ASLC6A4KCNH2TEAD4
SCHEMBL5583633 0.75 AR (0.51) ARHTR2ASLC6A4KCNH2TEAD4
SCHEMBL9685431 0.75 TEAD4 (0.38) ARHTR2ASLC6A4KCNH2TEAD4
SCHEMBL5583636 0.74 SLC6A4 (0.43) ARHTR2ASLC6A4KCNH2MAPT
SCHEMBL10001973 0.74 AR (0.51) ARHTR2ASLC6A4KCNH2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US claimed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP claimed
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US disclosed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP disclosed