Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 6/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.34 |
| ▸ | CCR3 | P51677 | 2/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5591222 | 0.96 | CTSL (0.43) | CTSLCTSSCTSKCTSBJAK2 | |
| SCHEMBL8245495 | 0.94 | CTSL (0.47) | CTSLCTSSCTSKCTSBCXCR3 | |
| SCHEMBL5591269 | 0.90 | CTSL (0.57) | CTSLCTSSCTSKCTSBJAK2 | |
| SCHEMBL5591381 | 0.87 | CTSL (0.60) | CTSLCTSSCTSKCTSBDDR1 | |
| Trifluoroacetic Acid SCHEMBL5591672 | 0.84 | CTSS (0.56) | CTSLCTSSCTSKCTSB | |
| SCHEMBL5592747 | 0.82 | CTSL (0.52) | CTSLCTSSCTSKCTSBJAK2 | |
| SCHEMBL5590944 | 0.81 | CTSS (0.68) | CTSLCTSSCTSKCTSBCXCR3 | |
| SCHEMBL5591156 | 0.80 | CTSS (0.56) | CTSLCTSSCTSKCTSBCXCR3 | |
| SCHEMBL5591180 | 0.80 | CTSS (0.68) | CTSLCTSSCTSKCTSBCXCR3 | |
| Trifluoroacetic Acid SCHEMBL5592940 | 0.79 | CTSL (0.48) | CTSLCTSSCTSKCTSBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025774-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | claimed |
| WO-2007025774-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |