Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592318 | 0.86 | MEN1 (0.36) | BTKMEN1KMT2APOLBPARP14 | |
| SCHEMBL5592378 | 0.83 | HSD11B1 (0.37) | TRPV4ROCK2ALDH1A1POLBRORC | |
| SCHEMBL5592321 | 0.80 | SIGMAR1 (0.34) | ROCK2ALDH1A1RORC | |
| SCHEMBL5599159 | 0.78 | ELANE (0.35) | MAPTPARP14 | |
| SCHEMBL5592317 | 0.77 | ALDH1A1 (0.37) | TRPV4ROCK2ALDH1A1GAAALOX15 | |
| SCHEMBL5592394 | 0.72 | MEN1 (0.35) | BTKMEN1KMT2APOLBDHFR | |
| SCHEMBL5809686 | 0.70 | EGLN1 (0.39) | ROCK2BTKALDH1A1GAAALOX15 | |
| SCHEMBL5592174 | 0.70 | SLC6A2 (0.35) | ALDH1A1MAPTHSD17B10MEN1KMT2A | |
| SCHEMBL5739775 | 0.69 | HSD11B1 (0.37) | TRPV4ROCK2ALDH1A1HSD17B10POLB | |
| SCHEMBL5812938 | 0.69 | EGLN1 (0.36) | BTKMEN1KMT2APOLBPARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057742-A2 | NOVEL PIPERAZINONE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-05-24 | — | — | WO | disclosed |