Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165411 | 0.86 | ROCK2 (0.38) | ELANECNR2CHIAEGLN1MAPT | |
| SCHEMBL5592318 | 0.86 | MEN1 (0.36) | CNR2PARP14 | |
| SCHEMBL5592249 | 0.86 | ELANE (0.34) | ELANECNR2PARP14TNKS2CHIA | |
| SCHEMBL5164538 | 0.84 | ELANE (0.36) | ELANECNR2TNKS2CHIAEGLN1 | |
| SCHEMBL5166374 | 0.84 | ELANE (0.38) | ELANECNR2CHIAEGLN1 | |
| SCHEMBL5592191 | 0.83 | HSD11B1 (0.36) | ELANECHIA | |
| SCHEMBL5592384 | 0.80 | CHIA (0.35) | ELANECHIA | |
| SCHEMBL5592285 | 0.79 | ELANE (0.35) | ELANECHIA | |
| SCHEMBL5592387 | 0.78 | TRPV4 (0.35) | PARP14MAPT | |
| SCHEMBL5758903 | 0.76 | MCHR1 (0.38) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057742-A2 | NOVEL PIPERAZINONE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-05-24 | — | — | WO | disclosed |