Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.86 |
| ▸ | CTSS | P25774 | 2/20 | 0.86 |
| ▸ | CTSK | P43235 | 2/20 | 0.86 |
| ▸ | CTSB | P07858 | 1/20 | 0.86 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592618 | 0.99 | CTSL (0.87) | CTSLCTSSCTSKCTSBHDAC6 | |
| SCHEMBL5593246 | 0.97 | CTSL (0.87) | CTSLCTSSCTSKCTSBHDAC6 | |
| Trifluoroacetic Acid SCHEMBL5592621 | 0.94 | CTSL (0.78) | CTSLCTSSCTSKCTSBHDAC6 | |
| SCHEMBL5592896 | 0.92 | CTSS (1.00) | CTSLCTSSCTSKCTSBHDAC6 | |
| SCHEMBL8245186 | 0.92 | CTSL (0.83) | CTSLCTSSCTSKCTSBALDH1A1 | |
| SCHEMBL5592822 | 0.91 | CTSS (0.88) | CTSLCTSSCTSKCTSBHDAC6 | |
| SCHEMBL8242433 | 0.91 | CTSL (0.71) | CTSLCTSSCTSKCTSBHDAC6 | |
| SCHEMBL5592866 | 0.90 | CTSL (0.72) | CTSLCTSSCTSKCTSBHDAC6 | |
| SCHEMBL5592915 | 0.88 | CTSS (0.72) | CTSLCTSSCTSKCTSBHDAC6 | |
| Trifluoroacetic Acid SCHEMBL3319243 | 0.88 | CTSS (0.90) | CTSLCTSSCTSKCTSBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025775-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | claimed |
| WO-2007025775-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007025776-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |