Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | SSTR2 | P30874 | 3/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.40 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4173054 | 1.00 | ADRB2 (0.44) | ADRB2NCF1PBKPRKCQPDE10A | |
| SCHEMBL5137952 | 0.90 | NCF1 (0.56) | ADRB2NCF1PBKPDE10AAKT2 | |
| SCHEMBL30404498 | 0.82 | PBK (0.61) | ADRB2NCF1PBKROCK2ROCK1 | |
| SCHEMBL4018098 | 0.81 | NCF1 (0.63) | ADRB2NCF1AKT2SSTR2ROCK2 | |
| SCHEMBL29722367 | 0.80 | PIM2 (0.43) | ADRB2NCF1PRKCQHTR1ATLR8 | |
| SCHEMBL30659356 | 0.79 | ADRB2 (0.50) | ADRB2NCF1HTR1ASLC9A1SLC9A2 | |
| Hydrochloric Acid SCHEMBL30114327 | 0.79 | PBK (0.47) | ADRB2NCF1PBKPDE10AHTR1A | |
| SCHEMBL1421267 | 0.79 | ROCK2 (0.44) | PBKPRKCQPDE10AAKT2CYP2C19 | |
| SCHEMBL5603836 | 0.78 | NR3C1 (0.55) | HTR1ASSTR2 | |
| SCHEMBL4163672 | 0.76 | MTNR1A (0.44) | OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007114763-A1 | SULPHONAMIDE DERIVATES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |