Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | STAT1 | P42224 | 1/20 | 0.53 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1290623 | 0.97 | STAT3 (0.56) | STAT3STAT1TOP1TERT | |
| SCHEMBL29738339 | 0.94 | STAT3 (0.58) | STAT3STAT1TOP1TERT | |
| SCHEMBL31127549 | 0.93 | STAT3 (0.57) | STAT3STAT1TOP1TERT | |
| SCHEMBL30426808 | 0.92 | STAT3 (0.56) | STAT3STAT1TOP1TERT | |
| SCHEMBL1978627 | 0.92 | STAT3 (0.56) | STAT3STAT1TOP1TERT | |
| SCHEMBL19206150 | 0.89 | STAT3 (0.53) | STAT3STAT1TERT | |
| Hydrochloric Acid SCHEMBL2963616 | 0.87 | STAT3 (0.49) | STAT3STAT1TOP1TERT | |
| SCHEMBL3005847 | 0.85 | STAT3 (0.50) | STAT3STAT1TOP1TERT | |
| SCHEMBL1640967 | 0.83 | STAT3 (0.50) | STAT3STAT1 | |
| SCHEMBL4258776 | 0.82 | STAT3 (0.43) | STAT3STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297657-B2 | Process for the preparation of N-(phosphonomethyl)glycine by oxidizing N-substituted N-(phosphonomethyl)glycine | MONSANTO TECHNOLOGY LLC (US) | 2007-11-20 | — | — | US | claimed |
| EP-1716923-A1 | Oxidation catalyst for making glyphosate | Monsanto Technology, LLC (US) | 2006-11-02 | — | — | EP | disclosed |
| US-6759549-B2 | PREPARATION OF N-(PHOSPHONOMETHYL)GLYCINE, ITS SALTS, AND ITS ESTERS, WHEREIN THE METHOD OF PREPARATION COMPRISES A CARBOXYMETHYLATION STEP | MONSANTO TECHNOLOGY LLC | 2004-07-06 | — | — | US | disclosed |
| US-20030225298-A1 | Method of preparing amino carboxylic acids | MONSANTO TECHNOLOGY LLC | 2003-12-04 | — | — | US | disclosed |
| US-20030088122-A1 | Method of preparing amino carboxylic acids | JOHNSON TODD J (US) | 2003-05-08 | — | — | US | disclosed |
| US-20020002281-A1 | Method of preparing amino carboxylic acids | JOHNSON TODD J (US) | 2002-01-03 | — | — | US | disclosed |
| EP-1062221-A4 | PROCESS FOR MAKING GLYPHOSATE BY OXIDIZING N-SUBSTITUTED GLYPHOSATES | MONSANTO TECHNOLOGY LLC (US) | 2001-10-17 | — | — | EP | disclosed |
| EP-1104427-A2 | PROCESS FOR THE PREPARATION OF N-(PHOSPHONOMETHYL)GLYCINE BY OXIDIZING N-SUBSTITUTED N-(PHOSPHONOMETHYL)GLYCINE | MONSANTO COMPANY (US) | 2001-06-06 | — | — | EP | disclosed |
| EP-1062221-A1 | PROCESS FOR MAKING GLYPHOSATE BY OXIDIZING N-SUBSTITUTED GLYPHOSATES | MONSANTO COMPANY (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0973719-A4 | METHOD OF PREPARING AMINO CARBOXYLIC ACIDS | MONSANTO CO (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-2000009517-A2 | PROCESS FOR THE PREPARATION OF N-(PHOSPHONOMETHYL)GLYCINE BY OXIDIZING N-SUBSTITUTED N-(PHOSPHONOMETHYL)GLYCINE | MONSANTO COMPANY (US) | 2000-02-24 | — | — | WO | disclosed |
| EP-0973719-A1 | METHOD OF PREPARING AMINO CARBOXYLIC ACIDS | MONSANTO COMPANY (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1999041260-A1 | PROCESS FOR MAKING GLYPHOSATE BY OXIDIZING N-SUBSTITUTED GLYPHOSATES | MONSANTO COMPANY (US) | 1999-08-19 | — | — | WO | disclosed |
| WO-1998035930-A1 | METHOD OF PREPARING AMINO CARBOXYLIC ACIDS | MONSANTO COMPANY (US) | 1998-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020002281-A1 | Method of preparing amino carboxylic acids | CPS1, GNMT, HNMT | STAT3 3406/4885STAT1 2005/4885TOP1 3056/4885 |
| US-20030088122-A1 | Method of preparing amino carboxylic acids | CPS1, GNMT, HNMT | STAT3 3406/4885STAT1 2005/4885TOP1 3056/4885 |
| US-20030225298-A1 | Method of preparing amino carboxylic acids | CPS1, GNMT, HNMT | STAT3 3406/4885STAT1 2005/4885TOP1 3056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.