Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3513447 | 0.81 | KDM4E (0.36) | KDM4ECYP2C19LMNAHTTCDK2 | |
| SCHEMBL5596259 | 0.79 | LMNA (0.50) | KDM4ECYP2C19LMNAHTTMEN1 | |
| SCHEMBL2322094 | 0.79 | CCNT1 (0.35) | KDM4ELMNAHTTCDK2MEN1 | |
| SCHEMBL1874079 | 0.79 | KDM4E (0.61) | KDM4ECYP2C19SMOLMNAHTT | |
| SCHEMBL15740549 | 0.78 | EGFR (0.40) | GPR119EGFRCDK2JAK2KDR | |
| SCHEMBL11101846 | 0.76 | ACHE (0.38) | KDM4ECYP2C19LMNAMAPTALDH1A1 | |
| SCHEMBL1110443 | 0.76 | POLB (0.41) | KDM4ELMNAHTTCDK2MET | |
| SCHEMBL1466733 | 0.76 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGD | |
| SCHEMBL5597094 | 0.76 | HTR3A (0.42) | CDK2MEN1KMT2A | |
| SCHEMBL6441506 | 0.74 | DRD2 (0.50) | KDM4ECYP2C19MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696909-B1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | SERONO LAB (CH) | 2007-11-14 | — | — | EP | claimed |