SCHEMBL5598392

SCHEMBL5598392

O=C(Cl)c1cc(Br)ccc1NS(=O)(=O)c1ccc(Cl)c([N+](=O)[O-])c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC25A1 P53007 1/20 0.64
SLC10A6 Q3KNW5 3/20 0.61
SLC10A2 Q12908 2/20 0.61
SLC10A1 Q14973 2/20 0.61
DNMT1 P26358 2/20 0.57
DNMT3A Q9Y6K1 1/20 0.57
METAP2 P50579 2/20 0.54
VCAM1 P19320 4/20 0.51
CCKBR P32239 1/20 0.48
PKM P14618 1/20 0.46
LMNA P02545 1/20 0.46
HTT P42858 1/20 0.46
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
THRB P10828 1/20 0.44
MAPT P10636 1/20 0.43
CRHBP P24387 1/20 0.43
CRHR2 Q13324 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5597819 0.88 SLC25A1 (0.60) SLC25A1SLC10A6SLC10A2SLC10A1DNMT1
SCHEMBL5597716 0.85 ALDH1A1 (0.59) SLC25A1DNMT1METAP2CCKBRPKM
SCHEMBL30777866 0.84 SLC10A6 (0.75) SLC25A1SLC10A6SLC10A2SLC10A1DNMT1
SCHEMBL27089455 0.84 SLC10A6 (0.75) SLC25A1SLC10A6SLC10A2SLC10A1DNMT1
SCHEMBL5598236 0.84 SLC10A6 (0.86) SLC25A1SLC10A6SLC10A2SLC10A1DNMT1
SCHEMBL5597781 0.82 DDX3X (0.57) SLC10A6SLC10A2SLC10A1METAP2LMNA
SCHEMBL5597721 0.80 METAP2 (0.80) SLC10A6SLC10A2SLC10A1METAP2KDM1A
SCHEMBL5598077 0.80 MAPT (0.61) SLC25A1SLC10A6SLC10A2SLC10A1DNMT1
SCHEMBL10389335 0.78 SLC25A1 (0.75) SLC25A1SLC10A6SLC10A2SLC10A1DNMT1
SCHEMBL810667 0.78 MAPT (0.64) SLC25A1SLC10A6SLC10A2SLC10A1DNMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1815860-A2 Phosphate transport inhibitors GENZYME CORPORATION (US) 2007-08-08 EP disclosed
US-20070021509-A1 Phosphate transport inhibitors JOZEFIAK THOMAS H 2007-01-25 US disclosed
US-7119120-B2 Phosphate transport inhibitors GENZYME CORPORATION (US) 2006-10-10 US disclosed
EP-1465638-A2 PHOSPHATE TRANSPORT INHIBITORS GENZYME CORPORATION (US) 2004-10-13 EP disclosed
US-20040019113-A1 Phosphate transport inhibitors GELTEX PHARMACEUTICALS, INC. 2004-01-29 US disclosed
WO-2003057225-A2 PHOSPHATE TRANSPORT INHIBITORS GENZYME CORPORATION (US) 2003-07-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040019113-A1 Phosphate transport inhibitors SLC34A1, SLC34A2, SLC20A1 SLC25A1 103/4885SLC10A6 12/4885SLC10A2 81/4885
US-20070021509-A1 Phosphate transport inhibitors SLC34A2, SLC34A1, SLC20A1 SLC25A1 108/4885SLC10A6 10/4885SLC10A2 81/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.