Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.61 |
| ▸ | JUN | P05412 | 1/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.59 |
| ▸ | TFEB | P19484 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.50 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598952 | 1.00 | NFE2L2 (0.61) | NFE2L2NFKB1JUNHSD11B1TFEB | |
| SCHEMBL608507 | 0.87 | JUN (0.54) | NFE2L2NFKB1JUNHSD11B1TFEB | |
| SCHEMBL16093028 | 0.86 | NFE2L2 (0.84) | NFE2L2NFKB1JUNTFEBALDH1A1 | |
| SCHEMBL11487985 | 0.85 | NFE2L2 (0.46) | NFE2L2NFKB1JUNHSD11B1TFEB | |
| SCHEMBL78555 | 0.85 | CA1 (0.62) | NFKB1ALDH1A1TSHRMAPTRAB9A | |
| SCHEMBL7899013 | 0.85 | MAPT (0.66) | NFE2L2NFKB1JUNHSD11B1TFEB | |
| SCHEMBL78556 | 0.85 | CA1 (0.62) | NFKB1ALDH1A1TSHRMAPTRAB9A | |
| SCHEMBL14279409 | 0.85 | MAPT (0.66) | NFE2L2NFKB1JUNHSD11B1TFEB | |
| SCHEMBL2834883 | 0.85 | MAPT (0.66) | NFE2L2NFKB1JUNHSD11B1TFEB | |
| SCHEMBL31422587 | 0.85 | MAPT (0.66) | NFE2L2NFKB1JUNHSD11B1TFEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541582-A | MBH reaction of alpha, beta-unsaturated ketone and allyl acetate | UNIV ZHEJIANG | 2016-05-04 | — | — | CN | disclosed |
| US-20160039734-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | STC UNM (US) | 2016-02-11 | — | — | US | disclosed |
| US-9187397-B2 | Therapeutic curcumin derivatives | STC.UNM (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150011494-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | STC.UNM | 2015-01-08 | — | — | US | disclosed |
| US-8841326-B2 | Therapeutic curcumin derivatives | STC.UNM (US) | 2014-09-23 | — | — | US | disclosed |
| US-20070060644-A1 | Therapeutic curcumin derivatives | STC.UNM | 2007-03-15 | — | — | US | disclosed |
| US-20060276536-A1 | Cancer treatment using curcumin derivatives | STC.UNM | 2006-12-07 | — | — | US | disclosed |
| US-RE29358-E | ANTI-MALARIA AND ANTI-TUBERCULOSIS AGENTS | AMERICAN CYANAMID COMPANY (US) | 1977-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039734-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | FABP2, GLS2, FABP1 | NFE2L2 75/4885NFKB1 418/4885JUN 2204/4885 |
| US-20070060644-A1 | Therapeutic curcumin derivatives | FABP2, GLS2, FABP1 | NFE2L2 75/4885NFKB1 418/4885JUN 2204/4885 |
| US-20150011494-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | FABP2, GLS2, FABP1 | NFE2L2 75/4885NFKB1 418/4885JUN 2204/4885 |
| US-20060276536-A1 | Cancer treatment using curcumin derivatives | BRCA1, VHL, TP53 | NFE2L2 5/4885NFKB1 73/4885JUN 786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.