Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.40 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5600810 | 0.78 | NPC1 (0.43) | ALDH1A1SMN1; SMN2L3MBTL1GAALMNA | |
| SCHEMBL5782188 | 0.76 | MEN1 (0.41) | L3MBTL1LMNAMAPK1KMT2AMEN1 | |
| SCHEMBL5598982 | 0.73 | KMT2A (0.43) | ALDH1A1SMN1; SMN2L3MBTL1GAAHSP90AA1 | |
| SCHEMBL5784831 | 0.73 | KMT2A (0.42) | ALDH1A1SMN1; SMN2L3MBTL1GAAHSP90AA1 | |
| SCHEMBL29601441 | 0.69 | GAA (0.72) | ALDH1A1SMN1; SMN2L3MBTL1GAAHSP90AA1 | |
| SCHEMBL5786199 | 0.68 | SIGMAR1 (0.43) | ALDH1A1SMN1; SMN2HTTLMNAMAPT | |
| SCHEMBL5578832 | 0.67 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2L3MBTL1GAAHSP90AA1 | |
| SCHEMBL5599673 | 0.67 | POLB (0.46) | ALDH1A1SMN1; SMN2L3MBTL1GAAHTT | |
| SCHEMBL26413557 | 0.66 | CES2 (0.51) | ALDH1A1SMN1; SMN2GAAHSP90AA1HTT | |
| SCHEMBL12021898 | 0.65 | TSHR (0.64) | ALDH1A1SMN1; SMN2L3MBTL1GAAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |