Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 5/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 5/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 5/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5616077 | 0.99 | TPSAB1 (0.38) | TPSAB1TPSD1TPSG1DPP4SMYD3 | |
| SCHEMBL5599362 | 0.91 | TPSAB1 (0.37) | TPSAB1TPSD1TPSG1DPP4SMYD3 | |
| SCHEMBL5600486 | 0.85 | GNRHR (0.36) | TPSAB1TPSD1TPSG1DPP4SMYD3 | |
| SCHEMBL5599755 | 0.85 | KDM1A (0.35) | DPP4SMYD3KDM1AOPRM1OPRK1 | |
| SCHEMBL5599714 | 0.85 | LMNA (0.36) | DPP4KDM1AOPRM1OPRK1OPRL1 | |
| SCHEMBL5599739 | 0.84 | OPRM1 (0.36) | DPP4KDM1AALDH1A1OPRM1OPRK1 | |
| SCHEMBL5783985 | 0.84 | DPP4 (0.34) | DPP4KDM1AGNRHRKCNH2 | |
| SCHEMBL5782306 | 0.82 | HTR2A (0.40) | DPP4SMYD3KDM1ACYP2C19GNRHR | |
| SCHEMBL5599501 | 0.82 | KDM1A (0.37) | DPP4KDM1AALDH1A1OPRM1OPRK1 | |
| SCHEMBL5599358 | 0.82 | PARP1 (0.36) | DPP4KDM1AGNRHRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |