Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 3/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599427 | 0.92 | DPP4 (0.36) | GNRHRDPP4MEN1KMT2AALDH1A1 | |
| SCHEMBL5599230 | 0.85 | TPSAB1 (0.38) | GNRHRDPP4ALDH1A1CHRM2CHRM3 | |
| SCHEMBL5616077 | 0.84 | TPSAB1 (0.38) | GNRHRDPP4ALDH1A1CHRM2CHRM3 | |
| SCHEMBL5786885 | 0.84 | GNRHR (0.33) | GNRHRDPP4MEN1KMT2APSEN1 | |
| SCHEMBL5778387 | 0.83 | OPRM1 (0.35) | GNRHRDPP4PSEN1PSEN2APH1B | |
| SCHEMBL5780824 | 0.81 | GNRHR (0.37) | GNRHRDPP4CHRM2CHRM3PSEN1 | |
| SCHEMBL5599105 | 0.79 | CHRNB2 (0.34) | GNRHRDPP4KCNH2NAMPTPTGDR2 | |
| SCHEMBL5780422 | 0.79 | P2RX7 (0.36) | GNRHRDPP4ALDH1A1PSEN1PSEN2 | |
| SCHEMBL5599768 | 0.79 | GNRHR (0.36) | GNRHRDPP4PSEN1PSEN2APH1B | |
| SCHEMBL5786887 | 0.79 | GNRHR (0.41) | GNRHRCHRM2CHRM3PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |