Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6419075 | 1.00 | POLB (0.45) | POLBAGTR1KMT2ASIGMAR1CYP1A2 | |
| SCHEMBL5354574 | 0.97 | SIGMAR1 (0.46) | POLBAGTR1KMT2ASIGMAR1CYP1A2 | |
| SCHEMBL5358995 | 0.97 | SIGMAR1 (0.46) | POLBAGTR1KMT2ASIGMAR1CYP1A2 | |
| SCHEMBL5354775 | 0.89 | POLB (0.45) | POLBAGTR1KMT2ASIGMAR1CYP1A2 | |
| SCHEMBL5354773 | 0.89 | POLB (0.45) | POLBAGTR1KMT2ASIGMAR1CYP1A2 | |
| SCHEMBL14280783 | 0.83 | SIGMAR1 (0.42) | KMT2ASIGMAR1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14444799 | 0.82 | SIGMAR1 (0.39) | POLBAGTR1KMT2ASIGMAR1CYP1A2 | |
| SCHEMBL7053627 | 0.82 | SIGMAR1 (0.48) | POLBAGTR1KMT2ASIGMAR1F2 | |
| SCHEMBL7053624 | 0.82 | SIGMAR1 (0.48) | POLBAGTR1KMT2ASIGMAR1F2 | |
| SCHEMBL5845665 | 0.82 | SLC22A2 (0.39) | POLBAGTR1KMT2ASIGMAR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562705-A4 | NEW CATALYST STRUCTURE FOR OLEFIN POLYMERIZATION | FINA TECHNOLOGY (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1562705-A2 | NEW CATALYST STRUCTURE FOR OLEFIN POLYMERIZATION | FINA TECHNOLOGY, INC. (US) | 2005-08-17 | — | — | EP | disclosed |
| US-6894180-B2 | Coordination catalysts such as 2,6-(bis-1-(1-indanylimino)-ethyl)pyridine iron chloride complexes used for addition polymerization | FINA TECHNOLOGY, INC. (US) | 2005-05-17 | — | — | US | disclosed |
| US-20040138055-A1 | Catalyst structure for olefin polymerization | FINA TECHNOLOGY, INC. | 2004-07-15 | — | — | US | disclosed |
| WO-2004047972-A2 | NEW CATALYST STRUCTURE FOR OLEFIN POLYMERIZATION | FINA TECHNOLOGY, INC. (US) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138055-A1 | Catalyst structure for olefin polymerization | CPNE4, PPOX, AOC2 | POLB 856/4885AGTR1 4301/4885KMT2A 1020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.