SCHEMBL5606633

SCHEMBL5606633

O=S=Nc1c(F)cc(F)cc1F

nearest known ligand 0.35

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.35
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9606815 0.70 CES2 (0.37) ERN1CES2CES1
SCHEMBL5881043 0.69 ERN1 (0.37) ERN1CES2CES1
SCHEMBL4636241 0.69 ERN1 (0.37) ERN1CES2CES1
SCHEMBL3194530 0.69 CES2 (0.35) ERN1CES2CES1
SCHEMBL362875 0.65 CES2 (0.32) ERN1CES2CES1
SCHEMBL160448 0.65 GABRA1 (0.35) ERN1CES2CES1
SCHEMBL16049591 0.64 CES2 (0.32) ERN1CES2CES1
SCHEMBL12327634 0.62 CA9 (0.39) ERN1CES2CES1
SCHEMBL12670865 0.62 ALDH1A1 (0.39) CES2CES1
SCHEMBL13712122 0.62 CES2 (0.31) CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7268243-B2 Bis(salicylaldiminato)titanium complex catalysts, highly syndiotactic polypropylene by a chain-end control mechanism, block copolymer containing this CORNELL RESEARCH FOUNDATION, INC. (US) 2007-09-11 US disclosed
US-20070004883-A1 Bis(salicylaldiminato)titanium complex catalysts, highly syndiotactic polypropylene by a chain-end control mechanism, block copolymer containing this CORNELL RESEARCH FOUNDATION, INC. (US) 2007-01-04 US disclosed
US-7119154-B2 Bis (salicylaldiminato) titanium complex catalysts, highly syndiotactic polypropylene by a chain-end control mechanism, block copolymer containing this CORNELL RESEARCH FOUNDATION, INC. (US) 2006-10-10 US disclosed
US-20040260042-A1 Bis (Salicylaldiminato) titanium complex catalysts, highly syndiotactic polypropylene by a chain-end control mechanism, block copolymer containing this CORNELL RESEARCH FOUNDATION, INC. (US) 2004-12-23 US disclosed
US-6787624-B2 SYNDIOTACTIC POLYPROPYLENE WITH DEFECTS OF THE TYPE RMR HAVING (RRRR) CONTENT GREATER THAN 0.70 AND BLOCK COPOLYMER CONTAINING BLOCKS OF SYNDIOTACTIC POLYPROPYLENE AND/OR POLY(ALPHA-OLFIN-CO POLYPROPYLENE) CORNELL RESEARCH FOUNDATION, INC. 2004-09-07 US disclosed
US-20030176605-A1 Bis(salicylaldiminato)titanium complex catalysts,highly syndiotactic polypropylene by a chain-end control mechanism, block copolymers containing this NATIONAL SCIENCE FOUNDATION 2003-09-18 US disclosed
US-6562930-B2 Also block copolymers containing block(s) of the syndiotactic polypropylene and block(s) of poly(ethylene-co-propylene) and/or poly(alpha-olefin-co-propylene) CORNELL RESEARCH FOUNDATION, INC. 2003-05-13 US disclosed
WO-2003025025-A1 BIS(SALICYLALDIMINATO)TITANIUM COMPLEX CATALYSTS, HIGHLY SYNDIOTACTIC POLYPROPYLENE BY A CHAIN-END CONTROL MECHANISM, BLOCK COPOLYMERS CONTAINING THIS CORNELL RESEARCH FOUNDATION, INC. (US) 2003-03-27 WO disclosed
US-20030060584-A1 BIS(SALICYLALDIMINATO)TITANIUM COMPLEX CATALYSTS, HIGHLY SYNDIOTACTIC POLYPROPYLENE BY A CHAIN-END CONTROL MECHANISM, BLOCK COPOLYMERS CONTAINING THIS NATIONAL SCIENCE FOUNDATION 2003-03-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030060584-A1 BIS(SALICYLALDIMINATO)TITANIUM COMPLEX CATALYSTS, HIGHLY SYNDIOTACTIC POLYPROPYLENE BY A CHAIN-END CONTROL MECHANISM, BLOCK COPOLYMERS CONTAINING THIS SRPRA, SRRT, SRPRB ERN1 2604/4885CES2 4245/4885CES1 4184/4885
US-20070004883-A1 Bis(salicylaldiminato)titanium complex catalysts, highly syndiotactic polypropylene by a chain-end control mechanism, block copolymer containing this SRPRA, SPR, SRR ERN1 2852/4885CES2 4192/4885CES1 4336/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.