Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15461976 | 0.79 | ALDH1A1 (0.69) | ALDH1A1TDP1CRHBPCRHR2TP53 | |
| SCHEMBL5608922 | 0.79 | MAOA (0.40) | ALDH1A1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5608736 | 0.76 | TSHR (0.40) | ALDH1A1CYP3A4MAPK1LMNA | |
| SCHEMBL22007056 | 0.74 | ALDH1A1 (0.67) | ALDH1A1TDP1CRHBPCRHR2TP53 | |
| SCHEMBL5068702 | 0.70 | ALDH1A1 (0.56) | ALDH1A1TDP1CRHBPCRHR2TP53 | |
| SCHEMBL17742484 | 0.70 | ALDH1A1 (0.60) | ALDH1A1TDP1CRHBPCRHR2TP53 | |
| SCHEMBL23609775 | 0.69 | ALDH1A1 (0.55) | ALDH1A1TDP1CRHBPCRHR2TP53 | |
| SCHEMBL5259225 | 0.69 | CAPN9 (0.54) | ALDH1A1TDP1CYP3A4MEN1KMT2A | |
| SCHEMBL6820729 | 0.69 | PTPRC (0.50) | ALDH1A1TDP1CYP1A2CYP3A4HIF1A | |
| SCHEMBL17915595 | 0.68 | ALDH1A1 (0.58) | ALDH1A1TDP1CRHBPCRHR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |