Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7593898 | 0.84 | TSHR (0.39) | CTSKTSHRMAPTMAPK1ALDH1A1 | |
| SCHEMBL8058797 | 0.84 | TSHR (0.39) | CTSKTSHRMAPTMAPK1ALDH1A1 | |
| SCHEMBL3217709 | 0.84 | PRKCA (0.43) | CTSKTSHRMAPTMAPK1ALDH1A1 | |
| SCHEMBL3042513 | 0.83 | CTSK (0.47) | CTSKTSHRMAPTMAPK1ALDH1A1 | |
| SCHEMBL8667788 | 0.83 | TSHR (0.49) | CTSKTSHRMAPTMAPK1ALDH1A1 | |
| SCHEMBL5437471 | 0.83 | TSHR (0.38) | CTSKTSHRMAPTMAPK1ALDH1A1 | |
| SCHEMBL5132770 | 0.81 | MAPT (0.45) | CTSKTSHRMAPTMAPK1ALDH1A1 | |
| SCHEMBL720178 | 0.80 | TSHR (0.41) | CTSKTSHRMAPTMAPK1ALDH1A1 | |
| SCHEMBL15942359 | 0.80 | TSHR (0.40) | CTSKTSHRMAPTALDH1A1HPGD | |
| SCHEMBL11617657 | 0.79 | PRKCA (0.45) | TSHRMAPTMAPK1FAAHPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185159-A2 | BORTEZOMIB AND PROCESS FOR PRODUCING SAME | Dr. Reddy's Laboratories, Ltd. (IN) | 2010-05-19 | — | — | EP | claimed |
| WO-2009036281-A2 | BORTEZOMIB AND PROCESS FOR PRODUCING SAME | DR. REDDY'S LABORATORIES LTD. (IN) | 2009-03-19 | — | — | WO | claimed |
| US-6919471-B2 | Process for preparing alkyl/aryl chloroformates | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-07-19 | — | — | US | claimed |
| US-20050065361-A1 | Process for preparing alkyl/aryl chloroformates | COUNCIL OF SCIENTIFIC AND INDUSRIAL RESEARCH (IN) | 2005-03-24 | — | — | US | claimed |
| CN-112041319-B | Triazole, imidazole and pyrrole fused piperazine derivatives and their use as mGlu5Use of modulators of receptors | 利康化学与制药工业有限公司 | 2024-05-14 | — | — | CN | disclosed |
| US-11780853-B2 | Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors | PFIZER INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20220089613-A1 | NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER INC. | 2022-03-24 | — | — | US | disclosed |
| US-11220518-B2 | Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors | PFIZER INC. (US) | 2022-01-11 | — | — | US | disclosed |
| CN-112041319-A | Triazole, imidazole and pyrrole fused piperazine derivatives and their use as mGlu5Use of modulators of receptors | 利康化学与制药工业有限公司 | 2020-12-04 | — | — | CN | disclosed |
| US-10316045-B2 | Substituted pyrrolo[3,4-c]pyrazoles as pkc kinase inhibitors | PFIZER INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-20170217991-A1 | NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER INC. | 2017-08-03 | — | — | US | disclosed |
| US-9518060-B2 | Substituted pyrrolo[3,4-c]pyrazoles as PKC kinase inhibitors | PFIZER INC. (US) | 2016-12-13 | — | — | US | disclosed |
| WO-2004043921-A1 | NOVEL PROCESS FOR THE PREPARATION OF 4-ARYL-3-HYDROXYMETHYL-1-METHYLPIPERIDINES. | NATCO PHARMA LIMITED (IN) | 2004-05-27 | — | — | WO | disclosed |
| US-20030171386-A1 | Small molecules for the treatment of abnormal cell growth | PFIZER INC. | 2003-09-11 | — | — | US | disclosed |
| US-20030144506-A1 | Processes for the preparation of substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC. | 2003-07-31 | — | — | US | disclosed |
| WO-2003049740-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2003-06-19 | — | — | WO | disclosed |
| WO-2003045939-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2003-06-05 | — | — | WO | disclosed |
| EP-1292591-A2 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20020169165-A1 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER PRODUCTS INC. | 2002-11-14 | — | — | US | disclosed |
| WO-2001098277-A2 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2001-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217991-A1 | NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, GPR119 | CTSK 3133/4885TSHR 2487/4885MAPT 141/4885 |
| US-10316045-B2 | Substituted pyrrolo[3,4-c]pyrazoles as pkc kinase inhibitors | PRKCB, PRKCA, PRKCE | CTSK 1438/4885TSHR 1536/4885MAPT 741/4885 |
| US-11780853-B2 | Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors | PRKCB, PRKCA, PRKCQ | CTSK 1266/4885TSHR 1866/4885MAPT 488/4885 |
| US-20020169165-A1 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | CCNA1, CCNT1, CCNB1 | CTSK 2255/4885TSHR 2648/4885MAPT 4429/4885 |
| US-20030171386-A1 | Small molecules for the treatment of abnormal cell growth | ERBB2, EGFR, ERBB3 | CTSK 2516/4885TSHR 715/4885MAPT 3189/4885 |
| US-20030144506-A1 | Processes for the preparation of substituted bicyclic derivatives for the treatment of abnormal cell growth | CCNA1, CCNE1, CCNT1 | CTSK 1628/4885TSHR 1958/4885MAPT 4712/4885 |
| US-11220518-B2 | Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors | JAK3, PRKCB, PRKCA | CTSK 1914/4885TSHR 2106/4885MAPT 338/4885 |
| US-20220089613-A1 | NOVEL 3-AMINO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, GPR119 | CTSK 3133/4885TSHR 2487/4885MAPT 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.