Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | NPC1 | O15118 | 8/20 | 0.43 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM6A | O15550 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29563651 | 0.77 | TOP2A (0.82) | TOP2AALDH1A1NPC1HPGDKDM4E | |
| SCHEMBL1223141 | 0.77 | TOP2A (0.82) | TOP2AALDH1A1NPC1HPGDKDM4E | |
| SCHEMBL5202659 | 0.75 | TOP2A (0.57) | TOP2AALDH1A1NPC1HPGDKDM4E | |
| SCHEMBL1136612 | 0.75 | MAOB (0.48) | ALDH1A1NPC1HPGDKDM4ERAB9A | |
| SCHEMBL4623912 | 0.75 | METAP2 (0.35) | ALDH1A1NPC1KDM4EHSD17B10MAPT | |
| SCHEMBL171055 | 0.75 | TOP2A (0.62) | TOP2AALDH1A1NPC1HPGDKDM4E | |
| SCHEMBL29504749 | 0.75 | TOP2A (0.62) | TOP2AALDH1A1NPC1HPGDKDM4E | |
| SCHEMBL6746143 | 0.74 | NPC1 (0.55) | ALDH1A1NPC1HPGDKDM4ERAB9A | |
| SCHEMBL12854009 | 0.73 | TOP2A (0.60) | TOP2AALDH1A1NPC1HPGDKDM4E | |
| SCHEMBL787149 | 0.72 | TOP2A (0.53) | TOP2AALDH1A1NPC1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827860-A | Peptidyl heterocycles useful in the treatment of thrombin related disorders | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-10-27 | — | — | US | claimed |
| CN-118251492-A | PMP 22-targeting compounds for the treatment of summer-Mary-Tuber disease | 诺华股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-117957320-A | NRL-targeting compounds for the treatment of retinitis pigmentosa | 诺华股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117479935-A | Benzothiazole and quinoline derivatives for the treatment of kawasaki disease | 上海药苑生物科技有限公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-116903600-A | Condensed ring compound and organic electroluminescent device thereof | 长春海谱润斯科技股份有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-109476616-B | Piperazinyl methanone NAAA inhibitors | 加利福尼亚大学董事会 | 2023-10-13 | — | — | CN | disclosed |
| CN-116685586-A | Benzothiazole and quinoline derivatives and uses thereof | 上海药苑生物科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-109071455-B | Compounds and methods for modulating bruton's tyrosine kinase | 嘉兴和剂药业有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-114375296-A | Nucleic acid polypeptide compositions and uses thereof | 艾维迪提生物科学公司 | 2022-04-19 | — | — | CN | disclosed |
| CN-114375297-A | UNA imides and uses thereof | 艾维迪提生物科学公司 | 2022-04-19 | — | — | CN | disclosed |
| CN-113166191-A | Lipid-modified nucleic acid compounds and methods | DTX医药有限公司 | 2021-07-23 | — | — | CN | disclosed |
| US-10822353-B2 | Dithio ETP derivatives | CITY OF HOPE (US) | 2020-11-03 | — | — | US | disclosed |
| US-20200181097-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-06-11 | — | — | US | disclosed |
| CN-110785414-A | K-Ras modulators | 加利福尼亚大学董事会 | 2020-02-11 | — | — | CN | disclosed |
| CN-109476616-A | Piperazinyl methanone NAAA inhibitor | 加利福尼亚大学董事会 | 2019-03-15 | — | — | CN | disclosed |
| CN-109071455-A | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | 科尔沃斯制药股份有限公司 | 2018-12-21 | — | — | CN | disclosed |
| US-20170152362-A1 | FUNCTIONAL POLYMER MEMBRANE, STACK OR DEVICE PROVIDED WITH FUNCTIONAL POLYMER MEMBRANE, AND METHOD OF PRODUCING FUNCTIONAL POLYMER MEMBRANE | FUJIFILM CORPORATION (JP) | 2017-06-01 | — | — | US | disclosed |
| WO-2007037540-A1 | CELLULOSE ACYLATE FILM, METHOD FOR PRODUCING SAME, OPTICALLY COMPENSATORY FILM, ANTI-REFLECTION FILM, POLARIZING PLATE AND IMAGE DISPLAY DEVICE | FUJIFILM CORPORATION (JP) | 2007-04-05 | — | — | WO | disclosed |
| US-20020103164-A1 | Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith | ADOLOR CORPORATION | 2002-08-01 | — | — | US | disclosed |
| US-4877720-A | PHOTOGRAPHIC POLYMER WHICH UNDERGOES REDUCTION UPON DEVELOPMENT | FUJI PHOTO FILM CO., LTD. (JP) | 1989-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103164-A1 | Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith | OPRK1, OPRD1, HRH4 | TOP2A 2248/4885ALDH1A1 3412/4885NPC1 1013/4885 |
| US-10822353-B2 | Dithio ETP derivatives | ETV1, ETV6, DLD | TOP2A 69/4885ALDH1A1 1114/4885NPC1 3265/4885 |
| US-20200181097-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | CFTR, SLC26A4, CLCN2 | TOP2A 4308/4885ALDH1A1 2135/4885NPC1 579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.