Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856849 | 0.87 | POLB (0.47) | NPC1MAPTHDAC1HDAC6CTSS | |
| SCHEMBL9856843 | 0.82 | DUT (0.41) | NPC1MAPTLMNACTSSCTSK | |
| SCHEMBL562070 | 0.79 | KDM4E (0.49) | NPC1LMNARAB9AMEN1HTT | |
| SCHEMBL7920783 | 0.78 | KEAP1 (0.48) | NPC1MAPTLMNAHDAC1HDAC6 | |
| SCHEMBL561596 | 0.77 | KEAP1 (0.47) | NPC1MAPTLMNAHDAC1HDAC6 | |
| SCHEMBL12376675 | 0.75 | HDAC2 (0.61) | NPC1MAPTLMNAHDAC1HDAC6 | |
| Potassium Ion SCHEMBL561597 | 0.74 | HDAC3 (0.46) | NPC1LMNAHDAC1HDAC6RAB9A | |
| SCHEMBL2238587 | 0.74 | ALOX5 (0.49) | NPC1LMNARAB9AKMT2AL3MBTL1 | |
| SCHEMBL10352510 | 0.72 | TDP1 (0.46) | NPC1LMNARAB9AMEN1HTT | |
| SCHEMBL12376676 | 0.72 | HDAC1 (0.64) | NPC1MAPTLMNAHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240463-B1 | SUBSTITUTED AMINOOXYPROPION AMIDES | CIBA-GEIGY AG (CH) | 1990-11-22 | — | — | EP | claimed |
| US-4760179-A | Substituted aminoxy-propionamides | CIBA-GEIGY CORPORATION (US) | 1988-07-26 | — | — | US | claimed |
| US-5057563-A | Oxidation, heat, radiation stabilizers | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0240463-B1 | SUBSTITUTED AMINOOXYPROPION AMIDES | CIBA-GEIGY AG (CH) | 1990-11-22 | — | — | EP | disclosed |
| US-4929657-A | STABILIZERS AGAINST OXIDATION, RADIATION FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1990-05-29 | — | — | US | disclosed |
| US-4760179-A | Substituted aminoxy-propionamides | CIBA-GEIGY CORPORATION (US) | 1988-07-26 | — | — | US | disclosed |