SCHEMBL5620718

SCHEMBL5620718

C[SiH](C)N(CC(C)(C)C)C(=O)C(F)(F)F

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.30
CHRM4 P08173 1/20 0.30
CHRM5 P08912 1/20 0.30
CHRM1 P11229 1/20 0.30
CHRM3 P20309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6675892 0.77 CHRM2 (0.35) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL2354299 0.72 MLYCD (0.39) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL5136628 0.71 FAAH (0.41)
SCHEMBL20421304 0.70 MLYCD (0.31) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4439111 0.69 FAAH (0.44)
SCHEMBL3618071 0.69 CHRM2 (0.31) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL1063804 0.68
SCHEMBL3643142 0.67 CHRM2 (0.33) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL28198385 0.67
SCHEMBL444539 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4280891-A1 METHODS OF SELECTIVELY PROMOTING GASTROINTESTINAL MICROBIAL GROWTH DSM IP Assets B.V. (NL) 2023-11-29 EP disclosed
WO-2023214405-A1 REEXPRESSION OF HNF4A TO ALLEVIATE CANCER-ASSOCIATED CACHEXIA YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2023-11-09 WO disclosed
WO-2023077166-A1 METHODS AND COMPOSITIONS FOR ANALYTE QUANTIFICATION MATTERWORKS INC (US) 2023-05-04 WO disclosed
EP-4118090-A1 METHODS OF MODULATING GASTROINTESTINAL MICROBIAL METABOLIC PATHWAYS AND METABOLITES DSM IP Assets B.V. (NL) 2023-01-18 EP disclosed
EP-4022293-A1 OPTIMIZED ANALYTE DERIVATIZATION FOR SYNERGISTIC APPLICATION WITH CRYSTAL SPONGE METHOD Merck Patent GmbH (DE) 2022-07-06 EP disclosed
WO-2021183896-A1 METHODS OF MODULATING GASTROINTESTINAL MICROBIAL METABOLIC PATHWAYS AND METABOLITES DSM IP ASSETS, B.V. (NL) 2021-09-16 WO disclosed
EP-3876747-A1 METHODS OF MODULATING GASTROINTESTINAL METABOLITES DSM IP Assets B.V. (NL) 2021-09-15 EP disclosed
WO-2021037937-A1 OPTIMIZED ANALYTE DERIVATIZATION FOR SYNERGISTIC APPLICATION WITH CRYSTAL SPONGE METHOD MERCK PATENT GMBH (DE) 2021-03-04 WO disclosed
EP-3551194-A1 GLYCAN POLYMERS AND RELATED METHODS THEREOF Kaleido Biosciences, Inc. (US) 2019-10-16 EP disclosed
EP-3334437-A1 GLYCAN COMPOSITIONS AND USES THEREOF Kaleido Biosciences, Inc. (US) 2018-06-20 EP disclosed
EP-3223834-A2 PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR MODULATION OF THE MICROBIOME Evelo Biosciences, Inc. (US) 2017-10-04 EP disclosed
WO-2017035412-A1 GLYCAN COMPOSITIONS AND USES THEREOF KALEIDO BIOSCIENCES, INC. (US) 2017-03-02 WO disclosed
WO-2016172657-A2 GLYCAN THERAPEUTICS AND METHODS OF TREATMENT KALEIDO BIOSCIENCES, INC. (US) 2016-10-27 WO disclosed
EP-3071235-A1 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF Kaleido Biosciences, Inc. (US) 2016-09-28 EP disclosed
WO-2016122889-A1 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF KALEIDO BIOSCIENCES, INC. (US) 2016-08-04 WO disclosed
WO-2016086208-A1 PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT AND PREVENTION OF GRAFT VERSUS HOST DISEASE Epiva Biosciences, Inc. (US) 2016-06-02 WO disclosed
WO-2016086209-A1 PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT OF GASTROINTESTINAL DISORDERS Epiva Biosciences, Inc. (US) 2016-06-02 WO disclosed
WO-2016086205-A2 PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR MODULATION OF THE MICROBIOME Epiva Biosciences, Inc. (US) 2016-06-02 WO disclosed
WO-2016086210-A1 PROBIOTIC AND PREBIOTIC COMPOSTIONS, AND METHODS OF USE THEROF FOR TREATMENT AND PREVENTION OF GRAFT VERSUS HOST DISEASE Epiva Biosciences, Inc. (US) 2016-06-02 WO disclosed
US-20070203175-A1 Productioin of dolasetron TEVA PHARMACEUTICALS USA, INC. 2007-08-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070203175-A1 Productioin of dolasetron DDOST, ALG8, DUT CHRM2 3870/4885CHRM4 3891/4885CHRM5 3704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.