Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5634756 | 0.90 | CYP3A4 (0.36) | MAPK1LMNARAB9ACYP3A4TSHR | |
| SCHEMBL9198854 | 0.83 | CYP3A4 (0.36) | MAPK1LMNARAB9ACYP3A4CASP1 | |
| SCHEMBL25759298 | 0.80 | ALDH1A1 (0.38) | LMNATSHRPOLBALDH1A1KDM4E | |
| SCHEMBL9192901 | 0.79 | LMNA (0.35) | MAPK1LMNARAB9ACYP3A4TSHR | |
| SCHEMBL9853679 | 0.78 | SLC6A2 (0.30) | SLC6A2SLC6A4 | |
| SCHEMBL16372005 | 0.76 | SMN1; SMN2 (0.43) | MAPK1LMNARAB9ACYP3A4CHRM1 | |
| SCHEMBL27595630 | 0.72 | CYP3A4 (0.35) | MAPK1LMNARAB9ACYP3A4TSHR | |
| SCHEMBL19125195 | 0.72 | SRC (0.33) | MAPK1SLC6A2SLC6A4 | |
| SCHEMBL8317405 | 0.71 | KMT2A (0.50) | MAPK1RAB9ANPSR1SLC6A2ALDH1A1 | |
| SCHEMBL22574887 | 0.70 | CYP3A4 (0.35) | MAPK1LMNARAB9ACYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013149996-A9 | SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS | ALMIRALL, S.A. (ES) | 2014-02-20 | — | — | WO | disclosed |
| WO-2013149996-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS | ALMIRALL, S.A. (ES) | 2013-10-10 | — | — | WO | disclosed |
| US-20070161619-A1 | Pyrroloquinoline and piperidoquinoline derivatives, preparation thereof, compositions containing them and uses thereof | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
| US-20070161619-A1 | Pyrroloquinoline and piperidoquinoline derivatives, preparation thereof, compositions containing them and uses thereof | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
| US-20070161619-A1 | Pyrroloquinoline and piperidoquinoline derivatives, preparation thereof, compositions containing them and uses thereof | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161619-A1 | Pyrroloquinoline and piperidoquinoline derivatives, preparation thereof, compositions containing them and uses thereof | OPRL1, OPRD1, OPRK1 | MAPK1 3729/4885LMNA 3122/4885RAB9A 1193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.