Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 12/20 | 0.40 |
| ▸ | KLK1 | P06870 | 4/20 | 0.40 |
| ▸ | TMPRSS15 | P98073 | 8/20 | 0.39 |
| ▸ | ACR | P10323 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.37 |
| ▸ | C1R | P00736 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309972 | 0.85 | MAPT (0.47) | MAPTPOLBPRSS1KLK1TMPRSS15 | |
| SCHEMBL1645315 | 0.80 | MAPT (0.51) | MAPTPOLBPRSS1TMPRSS15ACR | |
| SCHEMBL5177919 | 0.79 | PRSS1 (0.37) | MAPTPRSS1KLK1TMPRSS15ACR | |
| SCHEMBL1399027 | 0.76 | PRSS1 (0.43) | PRSS1KLK1TMPRSS15ACRF2 | |
| SCHEMBL2917664 | 0.75 | ACR (0.40) | MAPTPRSS1KLK1TMPRSS15ACR | |
| SCHEMBL7309976 | 0.74 | KMT2A (0.38) | MAPTPOLBPRSS1KLK1TMPRSS15 | |
| SCHEMBL1399029 | 0.71 | KMT2A (0.44) | PRSS1KLK1TMPRSS15ACRF2 | |
| SCHEMBL4597132 | 0.70 | MAPT (0.41) | MAPTPRSS1TMPRSS15ACRF2 | |
| SCHEMBL4099466 | 0.69 | GAA (0.49) | ALDH1A1GAAL3MBTL1 | |
| SCHEMBL11305079 | 0.68 | ALDH1A1 (0.47) | MAPTPOLBPRSS1KLK1TMPRSS15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7229966-B2 | Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity | NASTECH PHARMACEUTICAL COMPANY INC. (US) | 2007-06-12 | — | — | US | disclosed |