Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 known ✓ | O75116 | 1/20 | 0.37 |
| ▸ | F2 known ✓ | P00734 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 2/20 | 0.41 |
| ▸ | LDHB | P07195 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.41 |
| ▸ | KLK1 | P06870 | 2/20 | 0.41 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.40 |
| ▸ | ACR | P10323 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645315 | 0.96 | MAPT (0.51) | MAPTPOLBLDHALDHBPRSS1 | |
| SCHEMBL7309976 | 0.89 | KMT2A (0.38) | MAPTPOLBLDHALDHBPRSS1 | |
| SCHEMBL1399027 | 0.87 | PRSS1 (0.43) | LDHALDHBPRSS1KLK1TMPRSS15 | |
| SCHEMBL5634875 | 0.85 | MAPT (0.46) | MAPTPOLBPRSS1KLK1TMPRSS15 | |
| SCHEMBL1399029 | 0.83 | KMT2A (0.44) | LDHALDHBPRSS1KLK1TMPRSS15 | |
| SCHEMBL9236101 | 0.82 | TMPRSS15 (0.46) | PRSS1KLK1TMPRSS15ACRSMN1; SMN2 | |
| SCHEMBL9235375 | 0.82 | TMPRSS15 (0.46) | PRSS1KLK1TMPRSS15ACRSMN1; SMN2 | |
| SCHEMBL9233756 | 0.82 | TMPRSS15 (0.46) | PRSS1KLK1TMPRSS15ACRSMN1; SMN2 | |
| SCHEMBL9231748 | 0.82 | ACR (0.40) | MAPTPRSS1KLK1TMPRSS15ACR | |
| SCHEMBL9235998 | 0.82 | ACR (0.40) | MAPTPRSS1KLK1TMPRSS15ACR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4021472-A | ANTIPLASMIN AND ANTITRYPSIN | ONO PHARMACEUTICAL CO., LTD. (JA) | 1977-05-03 | — | — | US | disclosed |