Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10922388 | 0.96 | OPRM1 (0.52) | OPRM1HTR2ATACR1TSHRUSP2 | |
| Bromide SCHEMBL10922384 | 0.96 | OPRM1 (0.52) | OPRM1HTR2ATACR1TSHRUSP2 | |
| SCHEMBL568885 | 0.85 | MEN1 (0.41) | OPRM1HTR2ACYP2C9MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28581691 | 0.83 | MEN1 (0.40) | OPRM1CYP2C9MEN1KMT2A | |
| SCHEMBL1553 | 0.81 | AKR1C1 (0.42) | OPRM1CYP2C9MEN1KMT2A | |
| SCHEMBL1152247 | 0.81 | AKR1C1 (0.47) | SLC6A4KCNH2SIGMAR1 | |
| SCHEMBL28231792 | 0.81 | DAO (0.35) | OPRM1TACR1SLC6A4KCNH2DRD2 | |
| SCHEMBL27594932 | 0.81 | DRD2 (0.55) | OPRM1CYP2D6AKT2HSD17B10SLC6A4 | |
| SCHEMBL28173283 | 0.81 | MMP2 (0.35) | OPRM1DRD2 | |
| SCHEMBL7018027 | 0.80 | OPRM1 (0.55) | OPRM1HTR2ATACR1TSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-3204380-B1 | NOVEL AMINOPYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN PRENYLATION | INST NAT SANTE RECH MED (FR) | 2019-08-07 | — | — | EP | disclosed |
| US-20140288081-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS, INC (US) | 2014-09-25 | — | — | US | disclosed |
| US-7094784-B2 | High affinity ligands for nociceptin receptor ORL-1 | SCHERING CORPORATION (US) | 2006-08-22 | — | — | US | disclosed |
| CN-1231467-C | High affinity ligands for nociceptin receptor ORL-1 | SCHERING CORP (US) | 2005-12-14 | — | — | CN | disclosed |
| EP-1100781-B1 | HIGH AFFINITY LIGANDS FOR NOCICEPTIN RECEPTOR ORL-1 | SCHERING CORP (US) | 2004-09-22 | — | — | EP | disclosed |
| US-20040152707-A1 | High affinity ligands for nociceptin receptor ORL-1 | MERCK SHARP & DOHME CORP. | 2004-08-05 | — | — | US | disclosed |
| US-20040067950-A1 | High affinity ligands for nociceptin receptor ORL-1 | SCHERING-PLOUGH CORPORATION | 2004-04-08 | — | — | US | disclosed |
| US-6716846-B2 | CONTROLLING PAIN IN MAMMALS | SCHERING CORPORATION | 2004-04-06 | — | — | US | disclosed |
| US-20030073690-A1 | High affinity ligands for nociceptin receptor ORL-1 | MERCK SHARP & DOHME CORP. | 2003-04-17 | — | — | US | disclosed |
| US-6455527-B2 | ANALGESICSANALGESICS, ANXIOLYTIC AGENTS, ANTHISTAMINES, ANTIDEPRESSANTS | SCHERING CORPORATION | 2002-09-24 | — | — | US | disclosed |
| EP-1200087-A1 | NOCICEPTIN RECEPTOR ORL-1 AGONISTS FOR USE IN TREATING COUGH | SCHERING CORPORATION (US) | 2002-05-02 | — | — | EP | disclosed |
| CN-1311777-A | High affinity ligands for nociceptin receptor ORL-1 | SCHERING CORP (US) | 2001-09-05 | — | — | CN | disclosed |
| US-20010011092-A1 | High affinity ligands for nociceptin receptor ORL-1 | MERCK SHARP & DOHME CORP. | 2001-08-02 | — | — | US | disclosed |
| US-6262066-B1 | High affinity ligands for nociceptin receptor ORL-1 | SCHERING CORPORATION | 2001-07-17 | — | — | US | disclosed |
| EP-1100781-A1 | HIGH AFFINITY LIGANDS FOR NOCICEPTIN RECEPTOR ORL-1 | SCHERING CORPORATION (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2001007050-A1 | NOCICEPTIN RECEPTOR ORL-1 AGONISTS FOR USE IN TREATING COUGH | SCHERING CORPORATION (US) | 2001-02-01 | — | — | WO | disclosed |
| WO-2000006545-A1 | HIGH AFFINITY LIGANDS FOR NOCICEPTIN RECEPTOR ORL-1 | SCHERING CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |
| US-5925642-A | ANTITUMOR, ANTIMETASTASIS AGENTS; DRUG RESISTANCE MODULATORS; SYNERGISTIC MIXTURES WITH ANTIBIOTICS AND CYTOSTATIC AGENTS; SIDE EFFECT REDUCTION | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1999-07-20 | — | — | US | disclosed |
| US-5668131-A | CONTROLLING HELICOBACTER BACTERIA | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1997-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152707-A1 | High affinity ligands for nociceptin receptor ORL-1 | OPRL1, OGFRL1, OPRD1 | OPRM1 5/4885HTR2A 553/4885TACR1 751/4885 |
| US-20030073690-A1 | High affinity ligands for nociceptin receptor ORL-1 | OPRL1, OGFRL1, OPRD1 | OPRM1 5/4885HTR2A 553/4885TACR1 751/4885 |
| US-20140288081-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | PDK1, PC, PDK2 | OPRM1 3590/4885HTR2A 4680/4885TACR1 4178/4885 |
| US-20010011092-A1 | High affinity ligands for nociceptin receptor ORL-1 | OPRL1, OGFRL1, OPRD1 | OPRM1 5/4885HTR2A 553/4885TACR1 751/4885 |
| US-20040067950-A1 | High affinity ligands for nociceptin receptor ORL-1 | OPRL1, OPRD1, OGFRL1 | OPRM1 5/4885HTR2A 545/4885TACR1 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.