Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14539183 | 0.84 | RIPK1 (0.41) | — | |
| SCHEMBL4343857 | 0.81 | HPGDS (0.55) | THRBGAASMN1; SMN2STSLMNA | |
| SCHEMBL5763660 | 0.80 | HTT (0.58) | THRBGAASMN1; SMN2STSLMNA | |
| SCHEMBL5763947 | 0.79 | HPGDS (0.53) | THRBGAASMN1; SMN2STSLMNA | |
| SCHEMBL29024490 | 0.79 | DRD2 (0.59) | THRBGAASMN1; SMN2STSLMNA | |
| SCHEMBL14514120 | 0.79 | THRB (0.51) | THRBGAASMN1; SMN2STSLMNA | |
| SCHEMBL29024484 | 0.79 | THRB (0.52) | THRBGAASMN1; SMN2STSLMNA | |
| SCHEMBL1137864 | 0.76 | GPR119 (0.53) | THRBGPR119PRMT5MAPTHPGDS | |
| SCHEMBL14829908 | 0.76 | KDM4E (0.49) | THRBGPR119MAPTKDM4EHTT | |
| SCHEMBL15878935 | 0.76 | MAPT (0.49) | THRBGPR119MAPTHPGDSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217714-B1 | CCR5 modulators | AGOURON PHARMACEUTICALS, INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-7217714-B1 | CCR5 modulators | AGOURON PHARMACEUTICALS, INC. (US) | 2007-05-15 | — | — | US | disclosed |