Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5648866 | 0.84 | LMNA (0.60) | SMN1; SMN2PPARGPOLBGAAALDH1A1 | |
| SCHEMBL5644858 | 0.80 | MEN1 (0.61) | SMN1; SMN2PPARGGPR139P2RX7POLB | |
| SCHEMBL30277735 | 0.79 | ALDH1A1 (0.44) | PPARGGPR139GAAALDH1A1LMNA | |
| SCHEMBL31359082 | 0.75 | L3MBTL1 (0.48) | SMN1; SMN2PPARGGPR139POLBGAA | |
| SCHEMBL31187732 | 0.75 | L3MBTL1 (0.48) | SMN1; SMN2PPARGGPR139POLBGAA | |
| SCHEMBL26896061 | 0.74 | CES2 (0.45) | PPARGGPR139POLBALDH1A1CYP1A2 | |
| SCHEMBL6359727 | 0.74 | GPR139 (0.74) | SMN1; SMN2GPR139POLBALDH1A1KDM4E | |
| SCHEMBL5644652 | 0.74 | NPC1 (0.51) | SMN1; SMN2PPARGGPR139GAAALDH1A1 | |
| SCHEMBL1884905 | 0.73 | L3MBTL1 (0.44) | PPARGGPR139POLBGAAALDH1A1 | |
| SCHEMBL1884907 | 0.73 | L3MBTL1 (0.44) | PPARGGPR139POLBGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |