Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5646821 | 0.87 | NPC1 (0.50) | NPC1PPARGKMT2AALDH1A1LMNA | |
| SCHEMBL20988804 | 0.79 | CA2 (0.50) | NPC1PPARGGAA | |
| SCHEMBL31187732 | 0.79 | L3MBTL1 (0.48) | PPARGKMT2ASMN1; SMN2HTTGPR139 | |
| SCHEMBL31359082 | 0.79 | L3MBTL1 (0.48) | PPARGKMT2ASMN1; SMN2HTTGPR139 | |
| SCHEMBL26896061 | 0.77 | CES2 (0.45) | PPARGKMT2AALDH1A1MEN1HTT | |
| SCHEMBL8300134 | 0.76 | CES2 (0.44) | PPARGKMT2AALDH1A1HTTGPR139 | |
| SCHEMBL30202978 | 0.74 | GPR139 (0.47) | KMT2AALDH1A1LMNAMEN1GPR139 | |
| SCHEMBL5646731 | 0.74 | SMN1; SMN2 (0.51) | NPC1PPARGALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5648866 | 0.74 | LMNA (0.60) | NPC1PPARGKMT2AALDH1A1LMNA | |
| SCHEMBL3853615 | 0.74 | GAA (0.56) | NPC1KMT2AALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |