Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GRM6 | O15303 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5647564 | 0.95 | MAPK8 (0.47) | MAPK8ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL5651276 | 0.93 | PLAT (0.40) | MAPK8ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL5650258 | 0.90 | LMNA (0.38) | MAPK8ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL5651246 | 0.88 | SMN1; SMN2 (0.42) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL2781580 | 0.85 | CNR2 (0.43) | ALDH1A1HPGDMAPTKDM4ENPC1 | |
| SCHEMBL5651454 | 0.84 | ALDH1A1 (0.54) | MAPK8ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL1266627 | 0.84 | MAPT (0.44) | ALDH1A1HPGDMAPTKDM4ENPC1 | |
| SCHEMBL1266481 | 0.83 | CNR2 (0.40) | ALDH1A1MAPTKDM4ENPC1RAB9A | |
| SCHEMBL5652931 | 0.82 | ACACB (0.53) | MAPK8ALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL5648783 | 0.82 | LMNA (0.45) | ALDH1A1HPGDMAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176215-B2 | Bicyclic oxopyridine and oxopyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2007-02-13 | — | — | US | claimed |
| US-20050059681-A1 | Far field light microscopical method system and computer program product for analysing at least one object having a subwavelength size | RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG (DE) | 2005-03-17 | — | — | US | claimed |
| US-20040254200-A1 | Bicyclic oxopyridine and oxopyrimidine derivatives | UCB PHARMA S.A. (BE) | 2004-12-16 | — | — | US | claimed |
| US-7176215-B2 | Bicyclic oxopyridine and oxopyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2007-02-13 | — | — | US | disclosed |
| US-20040254200-A1 | Bicyclic oxopyridine and oxopyrimidine derivatives | UCB PHARMA S.A. (BE) | 2004-12-16 | — | — | US | disclosed |
| EP-1438313-A1 | BICYCLIC OXOPYRIDINE AND OXOPYRIMIDINE DERIVATIVES | Celltech R & D Limited (GB) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003033502-A1 | BICYCLIC OXOPYRIDINE AND OXOPYRIMIDINE DERIVATIVES | CELLTECH R & D LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059681-A1 | Far field light microscopical method system and computer program product for analysing at least one object having a subwavelength size | CFL1, INF2, COG6 | MAPK8 4617/4885ALDH1A1 2400/4885HPGD 3158/4885 |
| US-20040254200-A1 | Bicyclic oxopyridine and oxopyrimidine derivatives | MAPK1, ALK, NAT1 | MAPK8 22/4885ALDH1A1 1498/4885HPGD 1929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.