Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.43 |
| ▸ | GGT1 | P19440 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651549 | 0.88 | KDM4E (0.44) | GGT1HDAC1NPC1RAB9AKDM4E | |
| SCHEMBL5653523 | 0.87 | KDM4E (0.54) | GGT1KMT2AHDAC1KDM4EMAPT | |
| SCHEMBL5653527 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2OPRM1OPRD1OPRK1FFAR1 | |
| SCHEMBL2248518 | 0.77 | GGT1 (0.67) | SMN1; SMN2GGT1KMT2AHDAC1NPC1 | |
| SCHEMBL5650385 | 0.77 | MAPT (0.42) | SMN1; SMN2KMT2AHDAC1ALDH1A1KDM4E | |
| SCHEMBL4363953 | 0.75 | HIF1A (0.45) | SMN1; SMN2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL4357430 | 0.74 | KDM4E (0.46) | SMN1; SMN2HDAC1NPC1RAB9AKDM4E | |
| SCHEMBL2246500 | 0.74 | GGT1 (0.61) | GGT1KMT2AALDH1A1MAPT | |
| SCHEMBL4369490 | 0.71 | KDM4E (0.44) | SMN1; SMN2KMT2AHDAC1ALDH1A1NPC1 | |
| SCHEMBL5655905 | 0.71 | KDM4E (0.42) | SMN1; SMN2KMT2AHDAC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | SMN1; SMN2 2624/4885OPRM1 3465/4885OPRD1 2927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.