Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338804 | 0.82 | TSHR (0.46) | TSHRALDH1A1KDM4EGAAMAPT | |
| SCHEMBL13452933 | 0.81 | CARM1 (0.46) | CARM1PRMT6PRMT8TSHRALDH1A1 | |
| SCHEMBL9200826 | 0.81 | CARM1 (0.46) | CARM1PRMT6PRMT8TSHRALDH1A1 | |
| SCHEMBL9016852 | 0.78 | TSHR (0.54) | TSHRALDH1A1KDM4EMAOBPOLB | |
| SCHEMBL172668 | 0.78 | TSHR (0.54) | CARM1PRMT6PRMT8TSHRALDH1A1 | |
| Dibemethine SCHEMBL10542007 | 0.76 | ALDH1A1 (0.70) | CARM1PRMT6PRMT8TSHRALDH1A1 | |
| Dibemethine SCHEMBL276863 | 0.76 | ALDH1A1 (0.70) | CARM1PRMT6PRMT8TSHRALDH1A1 | |
| SCHEMBL9700093 | 0.76 | DNM1 (0.55) | CARM1PRMT6PRMT8TSHRALDH1A1 | |
| SCHEMBL7337030 | 0.76 | PIK3CD (0.35) | AOC3 | |
| SCHEMBL3440739 | 0.75 | PYCR1 (0.56) | ALDH1A1MAPTLMNAPYCR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109233-B2 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-19 | — | — | US | disclosed |
| EP-1532115-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2006-01-11 | — | — | EP | disclosed |
| US-20050234038-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-10-20 | — | — | US | disclosed |
| EP-1532115-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2003104257-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234038-A1 | Protease inhibitors | SPINT2, CTRL, PRSS1 | CARM1 3820/4885PRMT6 1141/4885PRMT8 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.