Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | VNN1 | O95497 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5659052 | 0.83 | MAPK1 (0.48) | KMT2AHPGDSMN1; SMN2CYP2C19MAPT | |
| SCHEMBL5658844 | 0.79 | CXCR1 (0.53) | KMT2ASMN1; SMN2RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL32682868 | 0.77 | NR4A2 (0.59) | KMT2AHPGDMEN1 | |
| SCHEMBL5272168 | 0.77 | KMT2A (1.00) | KMT2AHPGDSMN1; SMN2RAB9ATSHR | |
| SCHEMBL5657166 | 0.77 | HCAR3 (0.40) | KMT2AHPGDSMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL5660210 | 0.74 | SMN1; SMN2 (0.55) | KMT2AHPGDSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL9273340 | 0.73 | KMT2A (0.84) | KMT2AHPGDSMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL9271522 | 0.72 | ALDH1A1 (0.82) | KMT2AHPGDSMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL6944020 | 0.72 | PKM (0.66) | KMT2AHPGDTSHRALDH1A1CYP2C9 | |
| SCHEMBL6946331 | 0.72 | KMT2A (0.58) | KMT2AHPGDSMN1; SMN2ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |