Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 1/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5660133 | 0.88 | NOTUM (0.67) | CXCR1CXCR2NOTUMRAB9ANPC1 | |
| SCHEMBL5660811 | 0.85 | GAA (0.60) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5659910 | 0.83 | MAPT (0.57) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5660210 | 0.82 | SMN1; SMN2 (0.55) | LMNARAB9ANPC1MEN1KMT2A | |
| SCHEMBL5658255 | 0.79 | KMT2A (0.61) | RAB9AMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3498895 | 0.75 | LMNA (0.78) | NOTUMLMNARAB9ANPC1MEN1 | |
| SCHEMBL5656193 | 0.74 | ALDH1A1 (0.51) | LMNARAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5657166 | 0.73 | HCAR3 (0.40) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9125307 | 0.73 | ALDH1A1 (0.65) | NOTUMLMNARAB9AMEN1KMT2A | |
| SCHEMBL5659052 | 0.72 | MAPK1 (0.48) | LMNAMEN1KMT2ASMN1; SMN2DAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |