SCHEMBL5657536

SCHEMBL5657536

O=C(O)CCCc1ccc(NC(=O)c2ccc(Br)cc2O)cc1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 8/20 0.57
NR1H4 Q96RI1 2/20 0.51
KLKB1 P03952 3/20 0.48
MAPT P10636 1/20 0.48
RAB9A P51151 1/20 0.48
PLG P00747 3/20 0.47
KLK1 P06870 3/20 0.47
KLK6 Q92876 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6381563 0.82 ALOX15 (0.70) ALOX15NR1H4MAPTRAB9APLG
SCHEMBL13814817 0.80 NR1H4 (0.71) NR1H4MAPT
SCHEMBL13593311 0.80 PLG (0.67) ALOX15NR1H4MAPTRAB9APLG
SCHEMBL13814818 0.79 NR1H4 (0.58) NR1H4MAPTRAB9A
SCHEMBL31661727 0.78 SLC16A3 (0.46) MAPTRAB9A
SCHEMBL5657531 0.78 SLC16A3 (0.46) MAPTRAB9A
SCHEMBL5656623 0.78 ALOX15 (0.72) ALOX15NR1H4MAPTRAB9APLG
SCHEMBL13814819 0.78 SMN1; SMN2 (0.64) ALOX15NR1H4MAPTRAB9A
SCHEMBL3290446 0.78 PLG (0.56) ALOX15NR1H4KLKB1PLGKLK1
SCHEMBL13593307 0.78 P2RX1 (0.66) ALOX15NR1H4KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106456662-A Compositions of pentosan polysulfate for oral administration and methods of use thereof 奥利金制药公司 2017-02-22 CN claimed
US-20260077020-A1 ORAL PEPTIDE PHARMACEUTICAL COMPOSITION THAT FACILITATES ENHANCED ORAL ABSORPTION LE ROUX DANIELLE MARIE (US) 2026-03-19 US disclosed
CN-106456662-A Compositions of pentosan polysulfate for oral administration and methods of use thereof 奥利金制药公司 2017-02-22 CN disclosed
US-20090324540-A1 COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS EMISPHERE TECHNOLOGIES, INC. (US) 2009-12-31 US disclosed
US-20090324540-A1 COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS EMISPHERE TECHNOLOGIES, INC. (US) 2009-12-31 US disclosed
US-7553872-B2 Compounds and compositions for delivering active agents EMISPHERE TECHNOLOGIES, INC. (US) 2009-06-30 US disclosed
US-7553872-B2 Compounds and compositions for delivering active agents EMISPHERE TECHNOLOGIES, INC. (US) 2009-06-30 US disclosed
US-7071214-B2 Compounds and compositions for delivering active agents EMISPHERE TECHNOLOGIES, INC. (US) 2006-07-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260077020-A1 ORAL PEPTIDE PHARMACEUTICAL COMPOSITION THAT FACILITATES ENHANCED ORAL ABSORPTION VIP, GIPR, SLC10A2 ALOX15 1799/4885NR1H4 264/4885KLKB1 1002/4885
US-20090324540-A1 COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS ABCB4, ABCB7, ALPP ALOX15 1253/4885NR1H4 399/4885KLKB1 672/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.