SCHEMBL5658852

SCHEMBL5658852

O=C(O)CCCCCCCNC(=O)c1ccc(Br)cc1

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.84
LMNA P02545 1/20 0.69
CYP1A2 P05177 1/20 0.68
CYP2C9 P11712 1/20 0.68
CYP2C19 P33261 1/20 0.68
HSP90AA1 P07900 1/20 0.64
HDAC4 P56524 7/20 0.59
HDAC6 Q9UBN7 7/20 0.59
HDAC3 O15379 7/20 0.59
HDAC1 Q13547 7/20 0.59
HDAC2 Q92769 7/20 0.59
HDAC10 Q969S8 6/20 0.59
HDAC11 Q96DB2 6/20 0.59
HDAC8 Q9BY41 6/20 0.59
HDAC9 Q9UKV0 6/20 0.59
HDAC5 Q9UQL6 6/20 0.59
HDAC7 Q8WUI4 5/20 0.59
POLB P06746 2/20 0.58
ALDH1A1 P00352 2/20 0.56
NPC1 O15118 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16010904 1.00 MAPK1 (0.84) MAPK1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL428355 0.92 MAPK1 (1.00) MAPK1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL9490115 0.90 HSP90AA1 (0.71) MAPK1HSP90AA1HDAC4HDAC6HDAC3
SCHEMBL9183154 0.87 MAPK1 (0.90) MAPK1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL17946072 0.86 CA1 (0.61) MAPK1LMNAHSP90AA1ALDH1A1NPC1
SCHEMBL1232986 0.86 HDAC1 (0.79) HDAC4HDAC6HDAC3HDAC1HDAC2
SCHEMBL5658185 0.85 MAPK1 (0.87) MAPK1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL10659200 0.85 MAPK1 (0.86) MAPK1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL5655215 0.85 MAPK1 (0.86) MAPK1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL3030903 0.85 HSP90AA1 (0.69) MAPK1HSP90AA1HDAC4HDAC6HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025151884-A1 USE OF GLYCOSAMINOGLYCAN SULFATED POLYSACCHARIDES SUCH AS SODIUM PENTOSAN POLYSULFATE IN COMBINATION WITH PERMEATION AGENTS TO TREAT ALZHEIMER'S DISEASE PARSONS C LOWELL (US) 2025-07-17 WO claimed
US-20170189443-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES AND CONDITIONS EMPLOYING ORAL ADMINISTRATION OF SODIUM PENTOSAN POLYSULFATE AND OTHER PENTOSAN POLYSULFATE SALTS PLATINUM MONTAUR LIFE SCIENCES, LLC AND AS AGENT (KY) 2017-07-06 US claimed
US-20260077020-A1 ORAL PEPTIDE PHARMACEUTICAL COMPOSITION THAT FACILITATES ENHANCED ORAL ABSORPTION LE ROUX DANIELLE MARIE (US) 2026-03-19 US disclosed
WO-2025151884-A1 USE OF GLYCOSAMINOGLYCAN SULFATED POLYSACCHARIDES SUCH AS SODIUM PENTOSAN POLYSULFATE IN COMBINATION WITH PERMEATION AGENTS TO TREAT ALZHEIMER'S DISEASE PARSONS C LOWELL (US) 2025-07-17 WO disclosed
US-20170189443-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES AND CONDITIONS EMPLOYING ORAL ADMINISTRATION OF SODIUM PENTOSAN POLYSULFATE AND OTHER PENTOSAN POLYSULFATE SALTS PLATINUM MONTAUR LIFE SCIENCES, LLC AND AS AGENT (KY) 2017-07-06 US disclosed
US-7553872-B2 Compounds and compositions for delivering active agents EMISPHERE TECHNOLOGIES, INC. (US) 2009-06-30 US disclosed
US-7553872-B2 Compounds and compositions for delivering active agents EMISPHERE TECHNOLOGIES, INC. (US) 2009-06-30 US disclosed
US-7071214-B2 Compounds and compositions for delivering active agents EMISPHERE TECHNOLOGIES, INC. (US) 2006-07-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260077020-A1 ORAL PEPTIDE PHARMACEUTICAL COMPOSITION THAT FACILITATES ENHANCED ORAL ABSORPTION VIP, GIPR, SLC10A2 MAPK1 2609/4885LMNA 1774/4885CYP1A2 4011/4885
US-20170189443-A1 COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES AND CONDITIONS EMPLOYING ORAL ADMINISTRATION OF SODIUM PENTOSAN POLYSULFATE AND OTHER PENTOSAN POLYSULFATE SALTS SI, SLC20A1, SLC20A2 MAPK1 3137/4885LMNA 4376/4885CYP1A2 1899/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.