Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5659351 | 0.77 | ALDH1A1 (0.49) | ALDH1A1KDM4ETSHRMAPK10SMN1; SMN2 | |
| SCHEMBL5658074 | 0.73 | ALDH1A1 (0.61) | ALDH1A1KDM4ETSHRMAPK10SMN1; SMN2 | |
| SCHEMBL5658477 | 0.73 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRMAPK10SMN1; SMN2 | |
| SCHEMBL5120763 | 0.71 | SMN1; SMN2 (0.71) | ALDH1A1TSHRSMN1; SMN2LMNAKMT2A | |
| SCHEMBL5660091 | 0.68 | RAB9A (0.47) | ALDH1A1KDM4ETSHRMAPK10SMN1; SMN2 | |
| SCHEMBL17622776 | 0.68 | TP53 (0.72) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL1158167 | 0.67 | SMN1; SMN2 (0.52) | ALDH1A1KDM4ETSHRMAPK10SMN1; SMN2 | |
| SCHEMBL31236795 | 0.67 | KMT2A (0.59) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL9311985 | 0.66 | KMT2A (0.75) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL6075497 | 0.66 | KMT2A (0.64) | ALDH1A1KDM4ETSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |