Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | PTAFR | P25105 | 12/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5663419 | 0.90 | BRD4 (0.47) | GABRA1GABRA5GABRA2GABRB2BRD4 | |
| SCHEMBL5663631 | 0.89 | OPRK1 (0.43) | GABRA1GABRA5GABRA2GABRB2BRD4 | |
| SCHEMBL5664181 | 0.86 | PTAFR (0.57) | GABRA1GABRA5GABRA2OPRK1GABRA3 | |
| SCHEMBL5662712 | 0.84 | PGR (0.35) | OPRK1HPGDPGRHTR1AADRA2A | |
| SCHEMBL12228314 | 0.83 | PGR (0.45) | GABRA1GABRA5GABRA2GABRB2BRD4 | |
| SCHEMBL5664142 | 0.81 | PTAFR (0.46) | GABRA1GABRA5GABRA2OPRK1GABRA3 | |
| SCHEMBL5663645 | 0.79 | HTR7 (0.39) | GABRA1GABRA5GABRA2GABRB2BRD4 | |
| SCHEMBL5663705 | 0.78 | CDK2 (0.40) | GABRA1GABRA5GABRA2GABRB2BRD4 | |
| SCHEMBL9864306 | 0.77 | BRD4 (0.44) | BRD4OPRK1PTAFRPDE4DPGR | |
| SCHEMBL9864263 | 0.77 | PTAFR (0.47) | BRD4OPRK1PTAFRPDE4DPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7015213-B1 | Use of diazepines for preparing medicines for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2006-03-21 | — | — | US | claimed |
| US-7015213-B1 | Use of diazepines for preparing medicines for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2006-03-21 | — | — | US | disclosed |