Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOX1 | Q06278 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 4/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.34 |
| ▸ | ADAM9 | Q13443 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13334530 | 0.84 | AOX1 (0.41) | AOX1TSHRLMNACYP3A4MMP9 | |
| SCHEMBL12258671 | 0.80 | AOX1 (0.45) | AOX1TSHRTDP1LMNASMN1; SMN2 | |
| SCHEMBL2958530 | 0.79 | FPR2 (0.39) | AOX1TSHRLMNACYP3A4GAA | |
| SCHEMBL5664855 | 0.79 | MEN1 (0.44) | AOX1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5663666 | 0.78 | CA1 (0.54) | AOX1TSHRLMNACYP3A4MEN1 | |
| SCHEMBL13361800 | 0.76 | MAPT (0.46) | TSHRTDP1LMNARAB9AMEN1 | |
| SCHEMBL5663483 | 0.76 | MEN1 (0.60) | TSHRTDP1LMNACYP1A2CYP3A4 | |
| SCHEMBL2031067 | 0.76 | TDP1 (0.43) | TSHRTDP1LMNACYP1A2CYP3A4 | |
| SCHEMBL479061 | 0.73 | CCNT1 (0.46) | TSHRTDP1LMNACYP1A2CYP3A4 | |
| SCHEMBL282472 | 0.72 | TSHR (0.67) | TSHRTDP1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432277-B2 | Phosphorus-containing macrocycles | ARAID GENE THERAPEUTICS, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432277-B2 | Phosphorus-containing macrocycles | ARAID GENE THERAPEUTICS, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| WO-2007024745-A2 | PHOSPHORUS-CONTAINING MACROCYCLES | ARIAD GENE THERAPEUTICS, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| EP-1244679-B1 | PURINE DERIVATIVES | ARIAD PHARMA INC (US) | 2006-11-15 | — | — | EP | disclosed |
| US-7132427-B2 | Quinazolines and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| US-7115589-B2 | Purine derivatives | ARIAD PHARMACEUTICALS, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1259520-B1 | NOVEL PURINES | ARIAD PHARMA INC (US) | 2006-05-24 | — | — | EP | disclosed |
| EP-1463742-A4 | NOVEL PYRAZOLO-AND PYRROLO-PYRIMIDINES AND USES THEREOF | ARIAD PHARMA INC (US) | 2006-05-10 | — | — | EP | disclosed |
| EP-1412367-A4 | NOVEL QUINOLINES AND USES THEREOF | ARIAD PHARMA INC (US) | 2006-05-03 | — | — | EP | disclosed |
| US-7019139-B2 | Quinolinones and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2006-03-28 | — | — | US | disclosed |
| EP-1259520-A2 | NOVEL PURINES | ARIAD PHARMACEUTICALS, INC. (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1246829-A1 | NOVEL HETEROCYCLES | ARIAD PHARMACEUTICALS, INC. (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1244679-A1 | PURINE DERIVATIVES | ARIAD PHARMACEUTICALS, INC. (US) | 2002-10-02 | — | — | EP | disclosed |
| US-20020132819-A1 | Novel purinse | ARIAD PHARMACETICALS, INC. | 2002-09-19 | — | — | US | disclosed |
| US-20020103161-A1 | Novel heterocycles | ARIAD PHARMACEUTICALS, INC. | 2002-08-01 | — | — | US | disclosed |
| WO-2001044260-A9 | NOVEL PURINES | ARIAD PHARMA INC (US) | 2002-07-04 | — | — | WO | disclosed |
| US-20020068721-A1 | Purine derivatives | ARIAD PHARMACEUTICALS, INC. | 2002-06-06 | — | — | US | disclosed |
| WO-2001044260-A2 | NOVEL PURINES | ARIAD PHARMACEUTICALS, INC. (US) | 2001-06-21 | — | — | WO | disclosed |
| WO-2001044259-A1 | PURINE DERIVATIVES | ARIAD PHARMACEUTICALS, INC. (US) | 2001-06-21 | — | — | WO | disclosed |
| WO-2001044258-A1 | NOVEL HETEROCYCLES | ARIAD PHARMACEUTICALS, INC. (US) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068721-A1 | Purine derivatives | HPRT1, PNP, TYMP | AOX1 822/4885TSHR 1744/4885TDP1 224/4885 |
| US-20020132819-A1 | Novel purinse | PURB, NUDT15, NT5C2 | AOX1 3967/4885TSHR 4657/4885TDP1 190/4885 |
| US-20020103161-A1 | Novel heterocycles | BMP2, SOST, BMP4 | AOX1 2758/4885TSHR 2286/4885TDP1 2801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.