Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 6/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3765440 | 0.82 | PARP1 (0.37) | PARP1PARP10SRD5A1NOTUMACHE | |
| SCHEMBL8561388 | 0.77 | PARP10 (0.43) | PARP1PARP10SRD5A1 | |
| SCHEMBL28705640 | 0.77 | ALDH1A1 (0.45) | CYP19A1 | |
| SCHEMBL51879 | 0.77 | HPGD (0.45) | PARP1PARP10SRD5A1NOTUM | |
| SCHEMBL11520308 | 0.77 | PARP10 (0.43) | PARP1PARP10SRD5A1NOTUMACHE | |
| SCHEMBL9024306 | 0.73 | TYMS (0.35) | — | |
| SCHEMBL29756225 | 0.73 | NOX1 (0.38) | PARP1PARP10NOTUMGPR84CYP19A1 | |
| SCHEMBL11007944 | 0.72 | PARP1 (0.33) | PARP1PARP10CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL11761546 | 0.72 | HTR7 (0.43) | KDM1A | |
| SCHEMBL29836089 | 0.71 | ALDH1A1 (0.47) | PARP1PARP10ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110862401-B | Method for preparing spiro indole derivative by basic ionic liquid one-pot method | 马鞍山市泰博化工科技有限公司 | 2021-05-14 | — | — | CN | claimed |
| CN-110862401-A | Method for preparing spiro indole derivative by basic ionic liquid one-pot method | 马鞍山市泰博化工科技有限公司 | 2020-03-06 | — | — | CN | claimed |
| CN-110862401-B | Method for preparing spiro indole derivative by basic ionic liquid one-pot method | 马鞍山市泰博化工科技有限公司 | 2021-05-14 | — | — | CN | disclosed |
| CN-110862401-A | Method for preparing spiro indole derivative by basic ionic liquid one-pot method | 马鞍山市泰博化工科技有限公司 | 2020-03-06 | — | — | CN | disclosed |
| US-20140296285-A1 | PREPARATION AND APPLICATION OF THE NEW ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | YANG GENGLIANG (CN) | 2014-10-02 | — | — | US | disclosed |
| EP-2423213-B1 | PREPARATION AND USE OF NOVEL ANTIBIOTIC, ANTICANCER COMPOUNDS AND DERIVATIVES THEREOF | YANG GENGLIANG (CN) | 2014-01-08 | — | — | EP | disclosed |
| EP-2423213-A1 | PREPARATION AND USE OF NOVEL ANTIBIOTIC, ANTICANCER COMPOUNDS AND DERIVATIVES THEREOF | Yang, Gengliang (CN) | 2012-02-29 | — | — | EP | disclosed |
| US-20120035206-A1 | PREPARATION AND APPLICATION OF NOVEL ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | YANG, Gengliang (CN) | 2012-02-09 | — | — | US | disclosed |
| CN-101565424-A | 6H-thiochromene [4, 3-d][1, 2, 4] triazole [1, 5-a] pyrimidine class compound with anti-inflammatory and antifungal activities | GENGLIANG YANG (CN) | 2009-10-28 | — | — | CN | disclosed |
| CN-101565425-A | 6H-thiochromene [3, 4-e] [1, 2, 4] triazole [1, 5-a] pyrimidine compound with anti-inflammatory and anti-fungal activity | GENGLIANG YANG (CN) | 2009-10-28 | — | — | CN | disclosed |
| CN-101469001-A | 6H-thiochromeno[4,3-d] [1,2,4] triazole [4,3-a] pyridine compound with antiphlogistic activity and antifungal activity | GENGLIANG YANG (CN) | 2009-07-01 | — | — | CN | disclosed |
| CN-101353351-A | Novel 2,3,3a,4-tetrahydro thiochromeno [4,3-c] pyrazole antiinflammatory antimycotic compound | GENGLIANG YANG (CN) | 2009-01-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035206-A1 | PREPARATION AND APPLICATION OF NOVEL ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | MRPL21, NRDC, SOST | PARP1 4535/4885PARP10 4230/4885SRD5A1 52/4885 |
| US-20140296285-A1 | PREPARATION AND APPLICATION OF THE NEW ANTIBACTERIAL AND ANTICANCER COMPOUNDS AND THEIR DERIVATIVES | MRPL21, MCL1, MYC | PARP1 2453/4885PARP10 3668/4885SRD5A1 2683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.