SCHEMBL5667181

SCHEMBL5667181

[O]C(=O)c1cc(Cl)ccc1Cl

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.68
TP53 P04637 3/20 0.68
TSHR P16473 3/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
CASP1 P29466 1/20 0.56
ERCC5 P28715 1/20 0.53
FEN1 P39748 1/20 0.53
MAPK1 P28482 1/20 0.50
HIF1A Q16665 1/20 0.50
LMNA P02545 2/20 0.49
MAPT P10636 2/20 0.49
KDM4E B2RXH2 2/20 0.49
CYP3A4 P08684 2/20 0.49
JAK2 O60674 1/20 0.49
JAK1 P23458 1/20 0.49
TYK2 P29597 1/20 0.49
ALOX15 P16050 1/20 0.49
CYP1A2 P05177 1/20 0.49
HPGD P15428 1/20 0.49
CYP2C19 P33261 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8160214 0.83 ALDH1A1 (0.71) ALDH1A1TP53TSHRSMN1; SMN2CASP1
SCHEMBL180845 0.83 SMN1; SMN2 (0.71) ALDH1A1TP53TSHRSMN1; SMN2CASP1
SCHEMBL10541315 0.81 ALDH1A1 (0.68) ALDH1A1TP53TSHRSMN1; SMN2CASP1
SCHEMBL699001 0.81 ALDH1A1 (0.68) ALDH1A1TP53TSHRSMN1; SMN2CASP1
SCHEMBL224469 0.81 ALDH1A1 (1.00) ALDH1A1TP53TSHRSMN1; SMN2CASP1
SCHEMBL363918 0.79 ALDH1A1 (0.65) ALDH1A1TP53TSHRSMN1; SMN2CASP1
Hydrochloric Acid SCHEMBL699002 0.79 ALDH1A1 (0.95) ALDH1A1TP53TSHRSMN1; SMN2CASP1
SCHEMBL9586276 0.79 ALDH1A1 (0.65) ALDH1A1TP53TSHRSMN1; SMN2CASP1
SCHEMBL30219241 0.79 ALDH1A1 (0.65) ALDH1A1TP53TSHRSMN1; SMN2CASP1
SCHEMBL6584266 0.79 ALDH1A1 (0.95) ALDH1A1TP53TSHRSMN1; SMN2CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6995273-B2 1H-pyrazolo[1,5-b]-1,2,4-triazole compound, coupler and silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 2006-02-07 US disclosed
US-6818388-B2 Silver halide color photographic photosensitive material and process for forming color image FUJI PHOTO FILM CO., LTD. (JP) 2004-11-16 US disclosed
US-20040072109-A1 Silver halide color photographic photosensitive material and process for forming color image FUJI PHOTO FILM CO., LTD. 2004-04-15 US disclosed
EP-1162504-B1 Coupler and silver halide color photographic light-sensitive material FUJI PHOTO FILM CO LTD (JP) 2004-02-18 EP disclosed
US-20040002607-A1 1H-pyrazolo[1,5-b] -1,2,4-triazole compound, coupler and silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. 2004-01-01 US disclosed
US-6649333-B2 Whiteness, production stability, performance stability with respect to long-term storage in an unexposed state FUJI PHOTO FILM CO., LTD. (JP) 2003-11-18 US disclosed
US-20030157443-A1 Silver halide color photographic photosensitive material and process for forming color image FUJI PHOTO FILM CO., LTD. 2003-08-21 US disclosed
US-6544724-B2 A pyrazolotriazole coupler having a specific structure including an amide linkage; improves solubility of coupler, light-fastness of dye FUJI PHOTO FILM CO., LTD. (JP) 2003-04-08 US disclosed
US-20020018973-A1 Coupler and silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. 2002-02-14 US disclosed
EP-1162504-A2 Coupler and silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 2001-12-12 EP disclosed
EP-0571959-B1 Photographic coupler and silver halide color photographic material FUJI PHOTO FILM CO LTD (JP) 1997-04-09 EP disclosed
EP-0688774-A1 Compounds for preparing a photographic magenta coupler FUJI PHOTO FILM CO., LTD. (JP) 1995-12-27 EP disclosed
US-5451501-A Light sensitive element with magenta coupler on support FUJI PHOTO FILM CO., LTD. (JP) 1995-09-19 US disclosed
EP-0571959-A2 Photographic coupler and silver halide color photographic material FUJI PHOTO FILM CO., LTD. (JP) 1993-12-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020018973-A1 Coupler and silver halide color photographic light-sensitive material CBR1, CBR3, GRHPR ALDH1A1 289/4885TP53 1948/4885TSHR 1134/4885
US-20040002607-A1 1H-pyrazolo[1,5-b] -1,2,4-triazole compound, coupler and silver halide color photographic light-sensitive material CBR3, CBR1, PPOX ALDH1A1 66/4885TP53 2500/4885TSHR 894/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.