Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4172788 | 0.78 | AOC3 (0.38) | AOC3SLC6A3SLC6A4NPC1RAB9A | |
| SCHEMBL2036346 | 0.77 | AOC3 (0.37) | AOC3SLC6A3SLC6A4NPC1RAB9A | |
| SCHEMBL1199883 | 0.73 | AOC3 (0.36) | AOC3SLC6A3SLC6A4NPC1RAB9A | |
| SCHEMBL3640169 | 0.72 | AOC3 (0.44) | AOC3NPC1RAB9AKDM4EMAPT | |
| SCHEMBL73543 | 0.71 | AOC3 (0.47) | AOC3SLC6A3SLC6A4NPC1RAB9A | |
| SCHEMBL10441226 | 0.70 | AOC3 (0.42) | AOC3NPC1RAB9AKDM4ELOXL2 | |
| SCHEMBL6573678 | 0.69 | AKR1C3 (0.33) | HRH3KDM4EMAPTLOXL2ALDH1A1 | |
| SCHEMBL5584506 | 0.68 | AOC3 (0.40) | AOC3SLC6A3SLC6A4NPC1RAB9A | |
| SCHEMBL28011903 | 0.68 | AOC3 (0.37) | AOC3SLC6A3SLC6A4NPC1RAB9A | |
| SCHEMBL3389545 | 0.68 | NOS1 (0.46) | SLC6A3ALDH1A1CYP2A6MAOBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003200-B1 | TETRAHYDROPYRIDINYL INDOLE DERIVATIVES AND THEIR SALTS FOR USE IN A METHOD FOR THERAPEUTIC TREATMENT OF THE HUMAN OR ANIMAL BODY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1986-08-13 | — | — | EP | claimed |
| EP-0022705-B1 | DERIVATIVES OF TETRAHYDROPYRIDINYL-INDOL AND THEIR SALTS, THEIR PREPARATION, THEIR APPLICATION AS MEDICINES, AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1983-04-06 | — | — | EP | claimed |
| EP-0003199-B1 | TETRAHYDROPYRIDINYL INDOLE DERIVATIVES AND THEIR SALTS, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1981-11-11 | — | — | EP | claimed |
| EP-0022705-A1 | Derivatives of tetrahydropyridinyl-indol and their salts, their preparation, their application as medicines, and compositions containing them | ROUSSEL-UCLAF (FR) | 1981-01-21 | — | — | EP | claimed |
| EP-0003199-A2 | Tetrahydropyridinyl indole derivatives and their salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | claimed |
| EP-0003200-A2 | Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | claimed |
| US-7235569-B2 | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use | WYETH (US) | 2007-06-26 | — | — | US | disclosed |
| US-20050004162-A1 | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use | WYETH | 2005-01-06 | — | — | US | disclosed |
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-09-12 | — | — | US | disclosed |
| US-6391882-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS | H. LUNDBECK A/S (DK) | 2002-05-21 | — | — | US | disclosed |
| EP-1089997-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H.Lundbeck A/S (DK) | 2001-04-11 | — | — | EP | disclosed |
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0022705-A1 | Derivatives of tetrahydropyridinyl-indol and their salts, their preparation, their application as medicines, and compositions containing them | ROUSSEL-UCLAF (FR) | 1981-01-21 | — | — | EP | disclosed |
| EP-0003199-A2 | Tetrahydropyridinyl indole derivatives and their salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
| EP-0003199-A2 | Tetrahydropyridinyl indole derivatives and their salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
| EP-0003199-A2 | Tetrahydropyridinyl indole derivatives and their salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
| EP-0003200-A2 | Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
| EP-0003200-A2 | Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
| EP-0003200-A2 | Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1979-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | HTR2C, HTR1A, HTR7 | AOC3 841/4885SLC6A3 93/4885SLC6A4 31/4885 |
| US-20050004162-A1 | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use | TPH1, TPH2, HTR4 | AOC3 2350/4885SLC6A3 58/4885SLC6A4 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.