Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INPPL1 | O15357 | 8/20 | 0.44 |
| ▸ | INPP5A | Q14642 | 5/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | INPP5B | P32019 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 9/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL5668904 | 0.87 | MAPT (0.55) | INPPL1INPP5AAKT1INPP5BMAPT | |
| SCHEMBL582185 | 0.85 | INPPL1 (0.59) | INPPL1INPP5AAKT1INPP5BMAPT | |
| Tromethamine SCHEMBL5669990 | 0.80 | INPPL1 (0.43) | INPPL1INPP5AAKT1INPP5BMAPT | |
| Tromethamine SCHEMBL7255885 | 0.78 | INPPL1 (0.44) | INPPL1INPP5AAKT1INPP5BMAPT | |
| SCHEMBL2568315 | 0.75 | MAPT (0.44) | INPPL1INPP5AAKT1INPP5BMAPT | |
| Tromethamine SCHEMBL23302381 | 0.73 | BLM (0.51) | INPPL1INPP5AS1PR1S1PR3BLM | |
| Tromethamine SCHEMBL345008 | 0.71 | APEX1 (0.37) | INPPL1INPP5AAKT1INPP5BMAPT | |
| Tromethamine SCHEMBL284296 | 0.71 | LMNA (0.53) | INPPL1INPP5AAKT1INPP5BS1PR1 | |
| Tromethamine SCHEMBL5906711 | 0.71 | INPPL1 (0.43) | INPPL1INPP5AAKT1INPP5BMAPT | |
| Tromethamine SCHEMBL8979418 | 0.71 | S1PR1 (0.40) | INPPL1INPP5AAKT1INPP5BS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116804821-A | Photosensitive resin composition, photo-cured product thereof, and printed wiring board having photo-cured film of photosensitive resin composition | 株式会社田村制作所 | 2023-09-26 | — | — | CN | disclosed |
| WO-2022114175-A1 | PHOTOSENSITIVE RESIN COMPOSITION | 株式会社タムラ製作所 | 2022-06-02 | — | — | WO | disclosed |
| CN-108699302-B | Cyclic olefin copolymer composition and crosslinked product thereof | 三井化学株式会社 | 2021-02-02 | — | — | CN | disclosed |
| CN-107429044-B | Epoxy resin composition | ADEKA股份有限公司 | 2020-06-23 | — | — | CN | disclosed |
| WO-2020085048-A1 | BATTERY AND PROTECTIVE TAPE FOR BATTERIES | パナソニックＩＰマネジメント株式会社 | 2020-04-30 | — | — | WO | disclosed |
| WO-2020009001-A1 | RESIN COMPOSITION, CURED PRODUCT THEREOF, FIBRE-REINFORCED PLASTIC, AND FIBRE-REINFORCED PLASTIC FLAMEPROOFING METHOD | 株式会社ADEKA | 2020-01-09 | — | — | WO | disclosed |