Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 9/20 | 0.58 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5682849 | 0.87 | CASP1 (0.60) | CASP1ALDH1A1FFAR1 | |
| SCHEMBL5682969 | 0.84 | CASP1 (0.55) | CASP1PGRHTTALDH1A1MAPK1 | |
| SCHEMBL5680993 | 0.80 | CASP1 (0.47) | CASP1L3MBTL1LMNAFFAR1 | |
| SCHEMBL6249693 | 0.79 | CASP1 (0.51) | CASP1HTTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL11829128 | 0.78 | CASP1 (0.53) | CASP1L3MBTL1LMNAFFAR1 | |
| SCHEMBL997994 | 0.78 | CASP1 (0.48) | CASP1PGRALDH1A1LMNA | |
| SCHEMBL7386055 | 0.77 | TRPV4 (0.46) | PGRHTTALDH1A1LMNATRPV4 | |
| SCHEMBL926865 | 0.77 | CA12 (0.49) | CASP1HTTALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL30307015 | 0.77 | TRPV4 (0.46) | PGRHTTALDH1A1LMNATRPV4 | |
| SCHEMBL5682816 | 0.75 | CASP1 (0.52) | CASP1PGRHTTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932600-B1 | SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITORS | WARNER LAMBERT CO (US) | 2006-02-08 | — | — | EP | disclosed |
| US-6083981-A | USEFUL FOR TREATMENT OF STROKE, INFLAMMATORY DISEASES, SEPTIC SHOCK, REPERFUSION INJURY, ALZHEIMER'S DISEASE, SHIGELLOSIS | WARNER-LAMBERT COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| US-6054487-A | ADMINISTERING AN INTERLEUKIN-ONE BETA CONVERTING ENZYME SUFFICIENT TO INHIBIT PRODUCTION OF GAMMA-INTERFERON | BASF AKTIENGESELLSCHAFT (DE) | 2000-04-25 | — | — | US | disclosed |
| EP-0932600-A2 | SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1$g(b) CONVERTING ENZYME INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016504-A2 | SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1β CONVERTING ENZYME INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |