Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 10/20 | 0.47 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5682849 | 0.87 | CASP1 (0.60) | CASP1FFAR1 | |
| SCHEMBL5682969 | 0.81 | CASP1 (0.55) | CASP1FFAR1L3MBTL1 | |
| SCHEMBL5679392 | 0.80 | CASP1 (0.58) | CASP1FFAR1L3MBTL1LMNA | |
| SCHEMBL8412424 | 0.78 | CA2 (0.43) | — | |
| SCHEMBL5682805 | 0.76 | CASP1 (0.69) | CASP1 | |
| SCHEMBL11829128 | 0.75 | CASP1 (0.53) | CASP1FFAR1L3MBTL1MMP13LMNA | |
| Ammonia Solution, Strong SCHEMBL6014529 | 0.75 | LTA4H (0.56) | LTA4HLMNAMAPT | |
| SCHEMBL995712 | 0.73 | CYP1A2 (0.51) | LTA4HPOLBATML3MBTL1LMNA | |
| SCHEMBL6249693 | 0.73 | CASP1 (0.51) | CASP1MRGPRX1FFAR1L3MBTL1LMNA | |
| SCHEMBL997994 | 0.73 | CASP1 (0.48) | CASP1LTA4HPOLBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932600-B1 | SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITORS | WARNER LAMBERT CO (US) | 2006-02-08 | — | — | EP | disclosed |
| US-6083981-A | USEFUL FOR TREATMENT OF STROKE, INFLAMMATORY DISEASES, SEPTIC SHOCK, REPERFUSION INJURY, ALZHEIMER'S DISEASE, SHIGELLOSIS | WARNER-LAMBERT COMPANY (US) | 2000-07-04 | — | — | US | disclosed |
| US-6054487-A | ADMINISTERING AN INTERLEUKIN-ONE BETA CONVERTING ENZYME SUFFICIENT TO INHIBIT PRODUCTION OF GAMMA-INTERFERON | BASF AKTIENGESELLSCHAFT (DE) | 2000-04-25 | — | — | US | disclosed |