Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.54 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | BAX | Q07812 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL88339 | 0.91 | — | — | |
| SCHEMBL29017383 | 0.88 | — | — | |
| SCHEMBL28335624 | 0.88 | — | — | |
| SCHEMBL11013066 | 0.88 | — | — | |
| Water SCHEMBL11201989 | 0.88 | — | — | |
| Diphenylether SCHEMBL360280 | 0.85 | LTA4H (0.75) | PARP10LTA4HTSHRCTNNB1SRD5A2 | |
| Diphenylether SCHEMBL1965337 | 0.85 | LTA4H (0.75) | PARP10LTA4HTSHRCTNNB1SRD5A2 | |
| Diphenylether SCHEMBL5606885 | 0.85 | LTA4H (0.75) | PARP10LTA4HTSHRCTNNB1SRD5A2 | |
| Bicarbonate SCHEMBL9619880 | 0.78 | PARP10 (0.45) | PARP10LTA4HTSHRCTNNB1ALOX15 | |
| Isopropyl Alcohol SCHEMBL18394362 | 0.78 | LMNA (0.52) | PARP10LTA4HTSHRNR1H2BAX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618088-A1 | STABILIZED ORGANIC PEROXIDE COMPOSITION AND PROCESS FOR MAKING THE SAME | CHEMTURA CORPORATION (US) | 2006-01-25 | — | — | EP | disclosed |
| US-6893584-B2 | Stabilized organic peroxide composition and process for making the same | CROMPTON CORPORATION (US) | 2005-05-17 | — | — | US | disclosed |
| WO-2004096762-A1 | STABILIZED ORGANIC PEROXIDE COMPOSITION AND PROCESS FOR MAKING THE SAME | CHEMTURA CORPORATION (US) | 2004-11-11 | — | — | WO | disclosed |
| US-20040211938-A1 | Stabilized organic peroxide composition and process for making the same | CROMPTON CORPORATION | 2004-10-28 | — | — | US | disclosed |
| EP-0810211-B1 | Organic peroxide stabilization with phosphomolybdic acid | CROMPTON CORP (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-0853082-B1 | Organic peroxide stabilization with oximes | CROMPTON CORP (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-0810213-B1 | Organic peroxide stabilization with beta-dicarbonyl or cyclic alpha-diketone compounds | CK WITCO CORP (US) | 2000-09-06 | — | — | EP | disclosed |
| EP-0810212-B1 | Organic peroxide stabilization with alpha-hydroxyalkyl peroxides | CK WITCO CORP (US) | 2000-04-05 | — | — | EP | disclosed |
| US-5892090-A | Organic peroxide stabilization with oximes | WITCO CORPORATION (US) | 1999-04-06 | — | — | US | disclosed |
| EP-0853082-A1 | Organic peroxide stabilization with oximes | WITCO CORPORATION (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5719304-A | Organic peroxide stabilization with phosphomolybdic acid | WITCO CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| US-5714626-A | PEROXYDICARBONATES OR DIACYL PEROXIDES AND CYCLIC OR ACYCLIC BETA-DICARBONYL STABILIZERS TO RETARD THE RATE OF DECOMPOSITON OF PEROXIDES WHICH ARE USED AS FREE-RADICAL INTITIATORS | WITCO CORPORATION (US) | 1998-02-03 | — | — | US | disclosed |
| CN-1167760-A | Organic peroxide stabilization with beta-dicarbonyl or cyclic alpha-diketone compounds | WITCO CORP (US) | 1997-12-17 | — | — | CN | disclosed |
| EP-0810213-A2 | Organic peroxide stabilization with beta-dicarbonyl or cyclic alpha-diketone compounds | WITCO CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| EP-0810211-A2 | Organic peroxide stabilization with phosphomolybdic acid | WITCO CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| EP-0810212-A2 | Organic peroxide stabilization with alpha-hydroxyalkyl peroxides | WITCO CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| US-5654463-A | Organic peroxide stabilization with α-hydroxyalkyl peroxides | WITCO CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| US-5654464-A | RETARDING THE RATE OF DECOMPOSITION OF ESPECIALLY PEROXYDICARBONATE AND DIACYL PEROXIDE COMPOSITIONS; NONEXPLOSIVE; HEAT RESISTANCE; FREE RADICAL CATALYSTS; ADDITION POLYMERIZATION CATALYSTS | WITCO CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| US-4515929-A | STABILIZED POLYMERIZATION CATALYSTS | PPG INDUSTRIES, INC. (US) | 1985-05-07 | — | — | US | disclosed |
| US-4515929-A | STABILIZED POLYMERIZATION CATALYSTS | PPG INDUSTRIES, INC. (US) | 1985-05-07 | — | — | US | disclosed |