Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442148 | 0.92 | — | — | |
| SCHEMBL7131367 | 0.84 | LTA4H (0.41) | PARP10ALOX15CTNNB1TSHRLTA4H | |
| Bicarbonate SCHEMBL5680603 | 0.78 | PARP10 (0.54) | PARP10ALOX15CTNNB1TSHRLTA4H | |
| SCHEMBL31265343 | 0.77 | MMP3 (0.46) | TDP1HSD17B10CYP3A4CYP2C19PKM | |
| SCHEMBL19564729 | 0.76 | KMT2A (0.35) | PARP10PARP1 | |
| SCHEMBL9972334 | 0.76 | LTA4H (0.43) | PARP10ALOX15CTNNB1TSHRLTA4H | |
| Diphenylether SCHEMBL360280 | 0.75 | LTA4H (0.75) | PARP10CTNNB1TSHRLTA4HHPGD | |
| Diphenylether SCHEMBL5606885 | 0.75 | LTA4H (0.75) | PARP10CTNNB1TSHRLTA4HHPGD | |
| Diphenylether SCHEMBL1965337 | 0.75 | LTA4H (0.75) | PARP10CTNNB1TSHRLTA4HHPGD | |
| SCHEMBL4592607 | 0.74 | ALOX15 (0.44) | PARP10ALOX15TSHRLTA4HSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229678-B1 | FLUID ORGANOSILICONIC COMPOSITION AND PROCESS FOR PREPARING IT | ENICHEM SYNTHESIS S.p.A. (IT) | 1992-03-11 | — | — | EP | disclosed |
| US-4746702-A | SEALANTS | ENICHEM SINTESI S.P.A. (IT) | 1988-05-24 | — | — | US | disclosed |
| EP-0229678-A2 | Fluid organosiliconic composition and process for preparing it | ENICHEM SYNTHESIS S.p.A. (IT) | 1987-07-22 | — | — | EP | disclosed |