Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Menadione. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.84 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.84 |
| ▸ | MAP2K1 known ✓ | Q02750 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.84 |
| ▸ | MAPT | P10636 | 5/20 | 0.84 |
| ▸ | CDC25B | P30305 | 5/20 | 0.84 |
| ▸ | CDC25A | P30304 | 4/20 | 0.84 |
| ▸ | HPGD | P15428 | 4/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.84 |
| ▸ | MEN1 | O00255 | 4/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.84 |
| ▸ | IDO1 | P14902 | 3/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.84 |
| ▸ | LMNA | P02545 | 3/20 | 0.84 |
| ▸ | TP53 | P04637 | 2/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.84 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.84 |
| ▸ | BLM | P54132 | 2/20 | 0.84 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menadione SCHEMBL28229328 | 1.00 | ALDH1A1 (0.84) | ALDH1A1MAPTCDC25BCDC25AHPGD | |
| Menadione SCHEMBL27354760 | 0.98 | ALDH1A1 (0.81) | ALDH1A1MAPTCDC25BCDC25AHPGD | |
| Menadione SCHEMBL29351164 | 0.92 | MAPT (1.00) | ALDH1A1MAPTCDC25BCDC25AHPGD | |
| Menadione SCHEMBL25970 | 0.92 | MAPT (1.00) | ALDH1A1MAPTCDC25BCDC25AHPGD | |
| Menadione SCHEMBL1364028 | 0.92 | MAPT (1.00) | ALDH1A1MAPTCDC25BCDC25AHPGD | |
| Menadione SCHEMBL19356853 | 0.92 | MAPT (1.00) | ALDH1A1MAPTCDC25BCDC25AHPGD | |
| Menadione SCHEMBL28043536 | 0.91 | ALDH1A1 (0.75) | ALDH1A1MAPTCDC25BCDC25AHPGD | |
| Menadione SCHEMBL9163371 | 0.90 | MAPT (0.95) | ALDH1A1MAPTCDC25BCDC25AHPGD | |
| Menadione SCHEMBL3411128 | 0.90 | MAPT (0.95) | ALDH1A1MAPTCDC25BCDC25AHPGD | |
| Menadione SCHEMBL9812440 | 0.90 | MAPT (0.95) | ALDH1A1MAPTCDC25BCDC25AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61215305-A | — | — | None | — | — | JP | disclosed |
| JP-56063905-A | — | — | None | — | — | JP | disclosed |
| US-20240165084-A1 | ASCORBIC ACID AND QUINONE COMPOUNDS IN COMBINATION WITH AN ANTIPARASITIC AGENT FOR TREATING A PARASITIC DISEASE | IC-MedTech Corp. | 2024-05-23 | — | — | US | disclosed |
| CN-115461096-A | Polymer encapsulated drug particles | 吉益医疗公司 | 2022-12-09 | — | — | CN | disclosed |
| US-20210283100-A1 | ASCORBIC ACID, QUINONE COMPOUND, AND SODIUM GLUCOSE COTRANSPORTER INHIBITOR FOR TREATING CANCER | IC MEDTECH CORP (US) | 2021-09-16 | — | — | US | disclosed |
| US-20200281225-A1 | FEED ADDITIVE COMPOSITION | INTERNATIONAL N&H DENMARK APS (DK) | 2020-09-10 | — | — | US | disclosed |
| WO-2016108036-A9 | COMPOSITION CONTAINING CHITIN AND DIGESTIBLE PROTEINS | YNSECT (FR) | 2019-10-17 | — | — | WO | disclosed |
| WO-2016108037-A9 | BEETLE POWDER | YNSECT (FR) | 2019-10-17 | — | — | WO | disclosed |
| US-20190054064-A1 | VITAMIN C AND VITAMIN K COMPOUND FOR TREATING PANCREATIC CANCER | IC MEDTECH CORP (US) | 2019-02-21 | — | — | US | disclosed |
| EP-3373741-A1 | FEED ADDITIVE COMPOSITION | DuPont Nutrition Biosciences ApS (DK) | 2018-09-19 | — | — | EP | disclosed |
| WO-2017083196-A1 | FEED ADDITIVE COMPOSITION | DUPONT NUTRITION BIOSCIENCES APS (DK) | 2017-05-18 | — | — | WO | disclosed |
| US-20160303072-A1 | VITAMINS C AND K FOR TREATING POLYCYSTIC DISEASES | IC-MEDTECH CORP (US) | 2016-10-20 | — | — | US | disclosed |
| US-20160106709-A1 | VITAMIN C AND CHROMIUM-FREE VITAMIN K, AND COMPOSITIONS THEREOF FOR TREATING AN NFKB-MEDIATED CONDITION OR DISEASE | SUMMA HEALTH SYSTEM | 2016-04-21 | — | — | US | disclosed |
| CN-105154484-A | Method for increasing yield of flavobacterium synthetic vitamin K2 (MK) by means of adding inductive substances | HEFEI INST PHYSICAL SCI CAS | 2015-12-16 | — | — | CN | disclosed |
| EP-1538136-B1 | Fertilizer composition to stimulate the absorption of nutritive substances in plants | VALAGRO SPA (IT) | 2006-03-08 | — | — | EP | disclosed |
| WO-2005054156-A1 | FERTILIZER COMPOSITION TO STIMULATE THE ABSORPTION OF NUTRITIVE SUBSTANCES IN PLANTS | VALAGRO S.P.A. (IT) | 2005-06-16 | — | — | WO | disclosed |
| EP-1538136-A1 | Fertilizer composition to stimulate the absorption of nutritive substances in plants | Valagro S.p.A. (IT) | 2005-06-08 | — | — | EP | disclosed |
| US-20050119127-A1 | Fertilizer composition to stimulate the absorption of nutritive substances in plants | VALAGRO S.P.A. (IT) | 2005-06-02 | — | — | US | disclosed |
| JP-S61215305-A | PLANT GROWTH REGULATOR | TOMOE KAGAKU KOGYO KK | 1986-09-25 | — | — | JP | disclosed |
| JP-S5663905-A | THIOL CARBAMATE HERBICIDAL COMPOSITION | ASAHI CHEM IND CO LTD | 1981-05-30 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283100-A1 | ASCORBIC ACID, QUINONE COMPOUND, AND SODIUM GLUCOSE COTRANSPORTER INHIBITOR FOR TREATING CANCER | SLC5A1, SLC5A2, SLC5A6 | MAOA 1009/4885MAOB 1054/4885MAP2K1 729/4885 |
| US-20190054064-A1 | VITAMIN C AND VITAMIN K COMPOUND FOR TREATING PANCREATIC CANCER | PROC, VKORC1, VKORC1L1 | MAOA 3697/4885MAOB 3162/4885MAP2K1 439/4885 |
| US-20160303072-A1 | VITAMINS C AND K FOR TREATING POLYCYSTIC DISEASES | PROC, PKD1, IKBKG | MAOA 4161/4885MAOB 3352/4885MAP2K1 3357/4885 |
| US-20240165084-A1 | ASCORBIC ACID AND QUINONE COMPOUNDS IN COMBINATION WITH AN ANTIPARASITIC AGENT FOR TREATING A PARASITIC DISEASE | NQO1, ADH7, CYP27B1 | MAOA 351/4885MAOB 468/4885MAP2K1 1095/4885 |
| US-20160106709-A1 | VITAMIN C AND CHROMIUM-FREE VITAMIN K, AND COMPOSITIONS THEREOF FOR TREATING AN NFKB-MEDIATED CONDITION OR DISEASE | PROC, NFKB2, NFKBIA | MAOA 3280/4885MAOB 1377/4885MAP2K1 2297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.