SCHEMBL5689283

SCHEMBL5689283

Cc1cccnc1CCc1ccc(OC(=O)N2CCC(On3ccnc3)CC2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.37
GAA P10253 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
GRIN2B Q13224 3/20 0.35
TBXAS1 P24557 1/20 0.35
NPY2R P49146 1/20 0.35
TRPA1 O75762 2/20 0.35
RAB9A P51151 2/20 0.34
NPC1 O15118 1/20 0.34
ALDH1A1 P00352 2/20 0.34
LMNA P02545 1/20 0.34
TRPV1 Q8NER1 1/20 0.34
MMP1 P03956 1/20 0.34
RPLP1 P05386 1/20 0.34
RPLP0 P05388 1/20 0.34
RPS17 P08708 1/20 0.34
RPSA P08865 1/20 0.34
RPS2 P15880 1/20 0.34
RPL35A P18077 1/20 0.34
RPL7 P18124 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5689036 0.92 SMO (0.38) FAAHGAATDP1GRIN2BNPY2R
SCHEMBL5691503 0.88 GRIN2B (0.41) GAAGRIN2BTBXAS1NPY2R
SCHEMBL5687686 0.86 RAB9A (0.38) GAATDP1GRIN2BNPY2RTRPA1
SCHEMBL5688665 0.82 KMT2A (0.40) FAAHGAANPY2RRAB9ANPC1
SCHEMBL5689981 0.82 AOC3 (0.39) FAAHGAAGRIN2BMMP1
SCHEMBL5691076 0.82 NOS1 (0.38) FAAHGAAGRIN2BNPY2RRAB9A
SCHEMBL5689039 0.81 FAAH (0.39) FAAHGAARAB9ANPC1
SCHEMBL5688744 0.81 GRIN2B (0.38) FAAHGAAGRIN2BNPY2RRAB9A
SCHEMBL5689128 0.81 FAAH (0.37) FAAHGAANPY2RRAB9ANPC1
SCHEMBL5691062 0.81 FAAH (0.40) FAAHTBXAS1NPY2RRAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US claimed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP claimed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO claimed
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US disclosed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP disclosed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160851-A1 Substituted piperidine carbamates LIPE, PNLIP, LIPC FAAH 160/4885GAA 42/4885TDP1 1363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.