SCHEMBL5690604

SCHEMBL5690604

COC(=O)[C@H](Cc1ccc(NC(=O)C2CCN(C(=O)OCc3ccccc3)CC2)cc1)NC(=O)[C@@H](N(C)S(=O)(=O)c1ccc(C)cc1)C(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 3/20 0.48
P2RX7 Q99572 2/20 0.45
ALDH1A1 P00352 2/20 0.45
GAA P10253 1/20 0.45
YAP1 P46937 1/20 0.44
HTT P42858 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CCKBR P32239 1/20 0.41
PSMB11 A5LHX3 1/20 0.41
PSMA7 O14818 1/20 0.41
PSMB1 P20618 1/20 0.41
PSMA1 P25786 1/20 0.41
PSMA2 P25787 1/20 0.41
PSMA3 P25788 1/20 0.41
PSMA4 P25789 1/20 0.41
PSMB8 P28062 1/20 0.41
PSMB9 P28065 1/20 0.41
PSMA5 P28066 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5690337 0.95 ENPP2 (0.49) ENPP2P2RX7ALDH1A1GAAYAP1
SCHEMBL5852341 0.78 PTPN2 (0.48) P2RX7ALDH1A1GAAYAP1NPC1
SCHEMBL5850463 0.77 PTPN2 (0.46) P2RX7ALDH1A1GAAYAP1NPC1
SCHEMBL5690382 0.76 ITGB1 (0.53) ENPP2ALDH1A1L3MBTL1
SCHEMBL6308859 0.76 ALDH1A1 (0.52) ENPP2ALDH1A1L3MBTL1
SCHEMBL5690873 0.76 ITGB1 (0.60) ENPP2ALDH1A1L3MBTL1
SCHEMBL5691183 0.76 ITGB1 (0.60) ENPP2ALDH1A1L3MBTL1
SCHEMBL5690356 0.74 ENPP2 (0.48) ENPP2ALDH1A1GAAHTTNPC1
SCHEMBL5679777 0.73 ITGB1 (0.59) ENPP2GAAYAP1HTTNPC1
Hydrochloric Acid SCHEMBL5681091 0.73 ENPP2 (0.66) ENPP2HTTNPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001974-B1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARM INC (US) 2006-05-24 EP claimed
EP-1001974-A1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP claimed
WO-1999006434-A1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS INC. (US) 1999-02-11 WO claimed
EP-1001974-B1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARM INC (US) 2006-05-24 EP disclosed
US-6291453-B1 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 ATHENA NEUROSCIENCES, INC. 2001-09-18 US disclosed
EP-1001974-A1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP disclosed
WO-1999006434-A1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS INC. (US) 1999-02-11 WO disclosed